Yale University School of Medicine, New Haven, Connecticut 06519, USA.
Parkinsonism Relat Disord. 2012 Aug;18(7):864-70. doi: 10.1016/j.parkreldis.2012.04.021. Epub 2012 May 18.
The automated neuropsychological assessment metrics battery-4 for PD offers the promise of a computerized approach to cognitive assessment.
To assess its utility, the ANAM4-PD was administered to 72 PD patients and 24 controls along with a traditional battery. Reliability was assessed by retesting 26 patients.
The cognitive efficiency score (CES; a global score) exhibited high reliability (r = 0.86). Constituent variables exhibited lower reliability. The CES correlated strongly with the traditional battery global score, but displayed weaker relationships to UPDRS scores than the traditional score. Multivariate analysis of variance revealed a significant difference between the patient and control groups in ANAM4-PD performance, with three ANAM4-PD tests, math, tower, and pursuit tracking, displaying sizeable differences. In discriminant analyses these variables were as effective as the total ANAM4-PD in classifying cases designated as impaired based on traditional variables. Principal components analyses uncovered fewer factors in the ANAM4-PD relative to the traditional battery. ANAM4-PD variables correlated at higher levels with traditional motor and processing speed variables than with untimed executive, intellectual or memory variables.
The ANAM4-PD displays high global reliability, but variable subtest reliability. The battery assesses a narrower range of cognitive functions than traditional tests, and discriminates between patients and controls less effectively. Three ANAM4-PD tests, pursuit tracking, math, and tower performed as well as the total ANAM4-PD in classifying patients as cognitively impaired. These findings could guide the refinement of the ANAM4-PD as an efficient method of screening for mild to moderate cognitive deficits in PD patients.
用于 PD 的自动化神经心理评估指标电池-4 提供了一种计算机化认知评估方法的前景。
为了评估其效用，将 ANAM4-PD 与传统电池一起施用于 72 名 PD 患者和 24 名对照者。通过重新测试 26 名患者来评估可靠性。
认知效率得分（CES；总得分）表现出较高的可靠性（r = 0.86）。组成变量的可靠性较低。CES 与传统电池总得分密切相关，但与 UPDRS 评分的相关性弱于传统得分。方差分析的多元分析显示，在 ANAM4-PD 表现方面，患者组和对照组之间存在显著差异，三个 ANAM4-PD 测试，数学，塔和追踪跟踪，显示出相当大的差异。在判别分析中，这些变量与传统变量指定为受损的情况下，与总 ANAM4-PD 一样有效地对病例进行分类。主成分分析显示，与传统电池相比，ANAM4-PD 变量中发现的因素较少。ANAM4-PD 变量与传统运动和处理速度变量的相关性高于与无定时执行，智力或记忆变量的相关性。
ANAM4-PD 显示出较高的总体可靠性，但子测试可靠性不同。该电池评估的认知功能范围比传统测试窄，对患者和对照组的区分效果较差。三个 ANAM4-PD 测试，追踪追踪，数学和塔的表现与总 ANAM4-PD 一样，可以将患者分类为认知受损。这些发现可以指导 ANAM4-PD 的改进，作为一种在 PD 患者中筛查轻度至中度认知缺陷的有效方法。
