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炎症性贫血的关键模型。

Critical models for the anemia of inflammation.

机构信息

HARVARD MEDICAL SCHOOL.

出版信息

Blood. 2014 Feb 20;123(8):1124-5. doi: 10.1182/blood-2014-01-546994.

DOI:10.1182/blood-2014-01-546994
PMID:24558192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3931186/
Abstract

In this issue of , Kim et al and Gardenghi et al present companion reports exploring the physiology of the anemia of critical illness following intraperitoneal injection of heat-killed bacteria into mice.

摘要

本期《 》中,Kim 等人和 Gardenghi 等人发表了两篇相关报告,探讨了经腹腔注射热灭活 细菌后小鼠发生危重病相关贫血的生理学机制。

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1
Critical models for the anemia of inflammation.炎症性贫血的关键模型。
Blood. 2014 Feb 20;123(8):1124-5. doi: 10.1182/blood-2014-01-546994.
2
Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortus.发热布鲁氏菌灭活菌注射小鼠从贫血中恢复的过程中,铁调素和白细胞介素-6 发挥了不同的作用。
Blood. 2014 Feb 20;123(8):1137-45. doi: 10.1182/blood-2013-08-521625. Epub 2013 Dec 19.
3
A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin.炎症性贫血的小鼠模型:发病机制复杂,部分依赖于铁调素。
Blood. 2014 Feb 20;123(8):1129-36. doi: 10.1182/blood-2013-08-521419. Epub 2013 Dec 19.
4
Depletion of Complement Enhances the Clearance of Brucella abortus in Mice.补体耗竭增强了小鼠体内流产布鲁氏菌的清除。
Infect Immun. 2018 Sep 21;86(10). doi: 10.1128/IAI.00567-18. Print 2018 Oct.
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Immunization of Mice with Recombinant Brucella abortus Organic Hydroperoxide Resistance (Ohr) Protein Protects Against a Virulent Brucella abortus 544 Infection.用重组流产布鲁氏菌有机氢过氧化物抗性(Ohr)蛋白免疫小鼠可抵御强毒流产布鲁氏菌544感染。
J Microbiol Biotechnol. 2016 Jan;26(1):190-6. doi: 10.4014/jmb.1505.05028.
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Evaluation of plasma sphingosine 1-phosphate, hepcidin and cardiovascular damage biomarkers (cardiac troponin I and homocysteine) in rats infected with brucellosis and vaccinated (Rev-1, RB-51).对感染布鲁氏菌病并接种疫苗(Rev-1、RB-51)的大鼠血浆中1-磷酸鞘氨醇、铁调素及心血管损伤生物标志物(心肌肌钙蛋白I和同型半胱氨酸)的评估
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Immunogenicity and protective effect of recombinant Brucella abortus Ndk (rNdk) against a virulent strain B. abortus 544 infection in BALB/c mice.重组布鲁氏菌 Ndk(rNdk)对 BALB/c 小鼠强毒菌株 B.abortus 544 感染的免疫原性和保护作用。
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[Indices of phagocytosis of S and R forms of Brucella in patients with acute and chronic brucellosis caused by Brucella abortus].[流产布鲁氏菌引起的急性和慢性布鲁氏菌病患者中布鲁氏菌S型和R型的吞噬作用指标]
Zh Mikrobiol Epidemiol Immunobiol. 1986 Dec(12):88-91.
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The significance of bacterial hypersensitivity in human brucellosis: studies on infection due to strain 19 Brucella abortus.细菌超敏反应在人类布鲁氏菌病中的意义:关于流产布鲁氏菌19株感染的研究
Ann Intern Med. 1957 Nov;47(5):861-74. doi: 10.7326/0003-4819-47-5-861.
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[Studies on quantitative agglutinin absorption in type differentiation of brucellosis in man. Part 2. On the differential diagnostic value of different agglutination titers of patient sera against Brucella abortus and Brucella melitensis].[人体布鲁氏菌病类型鉴别中定量凝集素吸收的研究。第2部分。患者血清对流产布鲁氏菌和羊布鲁氏菌不同凝集效价的鉴别诊断价值]
Arztl Forsch. 1959 Dec 10;13:586-91.

引用本文的文献

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TREX1 D18N mice fail to process erythroblast DNA resulting in inflammation and dysfunctional erythropoiesis.TREX1 D18N小鼠无法处理成红细胞DNA,导致炎症和红细胞生成功能障碍。
Autoimmunity. 2018 Nov;51(7):333-344. doi: 10.1080/08916934.2018.1522305. Epub 2018 Nov 13.
2
Deficiency of the BMP Type I receptor ALK3 partly protects mice from anemia of inflammation.骨形态发生蛋白I型受体ALK3的缺乏可部分保护小鼠免受炎症性贫血的影响。
BMC Physiol. 2018 Feb 27;18(1):3. doi: 10.1186/s12899-018-0037-z.
3
Effects of Testosterone on Erythropoiesis in a Female Mouse Model of Anemia of Inflammation.睾酮对炎症性贫血雌性小鼠模型中红细胞生成的影响。
Endocrinology. 2016 Jul;157(7):2937-46. doi: 10.1210/en.2016-1150. Epub 2016 Apr 13.

本文引用的文献

1
Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortus.发热布鲁氏菌灭活菌注射小鼠从贫血中恢复的过程中,铁调素和白细胞介素-6 发挥了不同的作用。
Blood. 2014 Feb 20;123(8):1137-45. doi: 10.1182/blood-2013-08-521625. Epub 2013 Dec 19.
2
A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin.炎症性贫血的小鼠模型:发病机制复杂,部分依赖于铁调素。
Blood. 2014 Feb 20;123(8):1129-36. doi: 10.1182/blood-2013-08-521419. Epub 2013 Dec 19.
3
The small molecule, genistein, increases hepcidin expression in human hepatocytes.小分子染料木黄酮可增加人肝细胞中血红素的表达。
Hepatology. 2013 Oct;58(4):1315-25. doi: 10.1002/hep.26490. Epub 2013 Aug 19.
4
Hepcidin and iron homeostasis.铁调素与铁稳态。
Biochim Biophys Acta. 2012 Sep;1823(9):1434-43. doi: 10.1016/j.bbamcr.2012.01.014. Epub 2012 Jan 26.
5
Down-regulation of hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman disease.长期使用抗白细胞介素 6 受体抗体(托珠单抗)治疗导致铁调素下调,改善了多发性骨髓瘤性castleman 病的炎症性贫血。
Blood. 2010 Nov 4;116(18):3627-34. doi: 10.1182/blood-2010-03-271791. Epub 2010 Jul 19.
6
Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia.抗hepcidin 抗体治疗可调节铁代谢,在炎症性贫血的小鼠模型中有效。
Blood. 2010 Apr 29;115(17):3616-24. doi: 10.1182/blood-2009-09-245977. Epub 2010 Jan 6.
7
Animal models of anemia of inflammation.炎症性贫血的动物模型
Semin Hematol. 2009 Oct;46(4):351-7. doi: 10.1053/j.seminhematol.2009.06.003.
8
Interleukin-6 induces hepcidin expression through STAT3.白细胞介素-6通过信号转导和转录激活因子3诱导铁调素表达。
Blood. 2006 Nov 1;108(9):3204-9. doi: 10.1182/blood-2006-06-027631. Epub 2006 Jul 11.
9
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin.白细胞介素-6通过诱导铁调节激素铁调素的合成来介导炎症性低铁血症。
J Clin Invest. 2004 May;113(9):1271-6. doi: 10.1172/JCI20945.
10
The CRIT Study: Anemia and blood transfusion in the critically ill--current clinical practice in the United States.CRIT研究:危重症患者的贫血与输血——美国当前的临床实践
Crit Care Med. 2004 Jan;32(1):39-52. doi: 10.1097/01.CCM.0000104112.34142.79.