Ghosh Rajeshwary, Ray Udayan, Jana Pradipta, Bhattacharya Rabindra, Banerjee Debipriya, Sinha Asru
Sinha Institute of Medical Science and Technology, Kolkata, India.
Royal Hobart Hospital, University of Tasmania, Australia.
PLoS One. 2014 Feb 18;9(2):e88639. doi: 10.1371/journal.pone.0088639. eCollection 2014.
Excessive aggregation of platelets at the site of plaque rupture on the coronary artery led to the formation of thrombus which is reported to precipitate acute myocardial infarction (AMI). Nitric oxide (NO) has been reported to inhibit platelet aggregation and induce thrombolysis through the in situ formation of plasmin. As the plasma NO level in AMI patients from two different ethnic groups was reduced to 0 µM (median) compared to 4.0 µM (median) in normal controls, the effect of restoration of the NO level to normal ranges on the rate of death due to AMI was determined.
The restoration of plasma NO level was achieved by a sticking small cotton pad (10×25 mm) containing 0.28 mmol sodium nitroprusside (SNP) in 0.9% NaCl to the abdominal skin of the participants using non-toxic adhesive tape which was reported to normalize the plasma NO level. The participants (8,283) were volunteers in an independent study who had different kinds of cancers and did not wish to use any conventional therapy for their condition but opted to receive SNP "pad" for their condition for 3 years. The use of SNP "pad" which normalized (≈4.0 µM) the plasma NO level that in consequence reduced the death rate due to AMI, among the participants, was found to be significantly reduced compared to the death due to AMI in normal population.
Our data suggested that the use of SNP "pad" significantly reduced the death due to AMI.
www.ctri.nic.in CTRI/2013/12/004236.
冠状动脉斑块破裂部位血小板过度聚集会导致血栓形成，据报道这会引发急性心肌梗死（AMI）。据报道，一氧化氮（NO）可抑制血小板聚集并通过原位形成纤溶酶诱导溶栓。由于两个不同种族的AMI患者血浆NO水平降至0 μM（中位数），而正常对照组为4.0 μM（中位数），因此确定了将NO水平恢复到正常范围对AMI所致死亡率的影响。
通过用无毒胶带将一块粘有含0.28 mmol硝普钠（SNP）的0.9%氯化钠溶液的小棉垫（10×25 mm）贴在参与者腹部皮肤上，实现血浆NO水平的恢复，据报道这可使血浆NO水平正常化。参与者（8283名）是一项独立研究中的志愿者，他们患有不同类型的癌症，不希望对自己的病情采用任何传统疗法，而是选择接受SNP“棉垫”治疗3年。结果发现，使用SNP“棉垫”使血浆NO水平正常化（≈4.0 μM），从而降低了参与者中因AMI导致的死亡率，与正常人群中因AMI导致的死亡相比显著降低。
我们的数据表明，使用SNP“棉垫”可显著降低因AMI导致的死亡。
www.ctri.nic.in CTRI/2013/12/004236 。
