Survivin 超越生理学：多步骤致癌作用的协调与治疗潜力。

Survivin beyond physiology: orchestration of multistep carcinogenesis and therapeutic potentials.

机构信息

First Department of Medicine, "Laiko" General Hospital, University of Athens, Medical School, Athens, Greece.

出版信息

Cancer Lett. 2014 Jun 1;347(2):175-82. doi: 10.1016/j.canlet.2014.02.014. Epub 2014 Feb 19.

DOI:10.1016/j.canlet.2014.02.014

Abstract

Survivin, a member of the inhibitor of apoptosis protein family, has been associated with protection from cell apoptosis and regulation of mitosis. Survivin exhibits low to undetectable expression in most finally differentiated adult tissues but is abundantly over-expressed in almost all cancers. The aberrant high expression of survivin in cancers is associated with advanced disease, increased rate of tumor recurrence, abbreviated overall survival and resistance to chemo- and radio- therapy. Survivin touches nearly every aspect of cancer and is involved in the initiation, maintenance and development of tumor. Therefore, its significance in cancer dictates the pursuit for anti-survivin cancer therapies.

摘要

Survivin（存活素）是凋亡抑制蛋白家族的一员，与细胞凋亡的保护和有丝分裂的调节有关。Survivin 在大多数终末分化的成人组织中表达水平较低或检测不到，但在几乎所有癌症中均过度表达。癌症中 survivin 的异常高表达与疾病进展、肿瘤复发率增加、总生存期缩短以及对化疗和放疗的耐药性有关。Survivin 几乎涉及癌症的各个方面，参与肿瘤的发生、维持和发展。因此，其在癌症中的意义决定了人们对抗 survivin 癌症治疗的追求。