Department of Comparative Biomedical Science, Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy.
Exp Dermatol. 2011 Jun;20(6):457-63. doi: 10.1111/j.1600-0625.2011.01273.x.
Survivin is a member of the inhibitor of apoptosis (IAP) protein family acting at the intersection between proliferation and cell survival. This protein exhibits low or undetectable expression in most adult tissues but is increased in the majority of cancers. Suggested to be one of the most cancer-specific proteins identified to date, survivin acts as a signalling node in tumour maintenance and, after first promising results, is now attracting increasing attention as a target in anti-cancer therapy. In the skin, survivin has been implicated in a number of pathological conditions such as psoriasis and tumours of melanocytic and epithelial origin. Its expression can correlate with tumour severity, metastasis and decreased patient survival and has been inversely correlated with the sensitivity to cytotoxic agents used in anti-cancer therapy. Survivin may also be of importance for normal epidermal homeostasis possibly supporting self-renewal of epidermal stem cells. In this review, the authors summarize and discuss current data of survivin in skin biology and provide a comprehensive compilation of survivin expression in skin pathologies with focus on future therapeutical use.
生存素是凋亡抑制蛋白（IAP）家族的成员，作用于增殖和细胞存活的交汇点。这种蛋白质在大多数成人组织中表达水平低或无法检测到，但在大多数癌症中增加。被认为是迄今为止鉴定出的最具癌症特异性的蛋白质之一，生存素作为肿瘤维持的信号节点，在最初的有希望的结果之后，现在作为抗癌治疗的靶点引起了越来越多的关注。在皮肤中，生存素已被牵连到许多病理状况，如银屑病和黑素细胞和上皮来源的肿瘤。其表达可以与肿瘤严重程度、转移和患者生存时间缩短相关，并与用于抗癌治疗的细胞毒性药物的敏感性呈负相关。生存素对于正常表皮稳态可能也很重要，可能支持表皮干细胞的自我更新。在这篇综述中，作者总结和讨论了生存素在皮肤生物学中的最新数据，并提供了生存素在皮肤病理学中的表达的全面汇编，重点是未来的治疗用途。
