来自皱叶酸模果实的香豆素类化合物。
Coumarinoids from the fruits of Micromelum falcatum.
机构信息
Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
Department of Science and Technology, Faculty of Liberal Arts and Science, Roi-Et Rajabhat University, Selapoom, Roi-Et 45120, Thailand.
出版信息
Fitoterapia. 2014 Apr;94:134-41. doi: 10.1016/j.fitote.2014.02.004. Epub 2014 Feb 19.
Four new compounds, microminutin B (1), microminutin C (2), micromarinate (3), and secomicromelin (4) as well as 17 known compounds were isolated from the fruits of Micromelum falcatum. All compounds were evaluated for antifungal activity against Pythium insidiosum using disc diffusion assay. P. insidiosum is a fungus-like microorganism for which antifungal agents now available are not effective. The results show that four compounds including secomicromelin (4), 7-methoxy-8-(4'-methyl-3'-furanyl)coumarin (10), micromarin B (17), and isomicromelin (19) could inhibit the mycelia growth of P. insidiosum.
从 Micromelum falcatum 的果实中分离得到了 4 种新化合物（microminutin B（1）、microminutin C（2）、micromarinate（3）和 secomicromelin（4））和 17 种已知化合物。采用圆盘扩散法评估所有化合物对腐霉病菌（Pythium insidiosum）的抗真菌活性。腐霉病菌是一种类似真菌的微生物，目前可用的抗真菌剂对此无效。结果表明，包括 secomicromelin（4）、7-甲氧基-8-（4'-甲基-3'-呋喃基）香豆素（10）、micromarin B（17）和 isomicromelin（19）在内的 4 种化合物可以抑制腐霉病菌的菌丝生长。
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