Department of Resources Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Department of Resources Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Fitoterapia. 2014 Apr;94:142-7. doi: 10.1016/j.fitote.2014.02.003. Epub 2014 Feb 20.
Four new eudesmane-type sesquiterpenes, named plebeiolide A-C (1-3) and plebeiafuran (4), together with a known eudesmanolide (5), were isolated from the basal leaves of Salvia plebeia R. Br. Their structures were elucidated by extensive spectroscopic analysis including 1D and 2D NMR, HR-ESI-MS spectra. The absolute configuration of compound 1 was confirmed by single-crystal X-ray analysis and CD spectra. The inhibitory activity of isolated compounds toward NO production in lipopolysaccharide-induced RAW264.7 cells was evaluated and compounds 3 and 4 showed moderate inhibitory activity. In addition, the sesquiterpene lactones in Lamiaceae plants may possess some chemosystematic implications at intergeneric and intrageneric levels.
从普通鼠尾草（Salvia plebeia R. Br.）的基生叶中分离得到了 4 个新的倍半萜类化合物，分别命名为 plebeiolide A-C（1-3）和 plebeiafuran（4），以及一个已知的 eudesmanolide（5）。通过 1D 和 2D NMR、HR-ESI-MS 光谱等广泛的光谱分析确定了它们的结构。通过单晶 X 射线分析和 CD 光谱确定了化合物 1 的绝对构型。对分离得到的化合物对脂多糖诱导的 RAW264.7 细胞中 NO 生成的抑制活性进行了评价，结果表明化合物 3 和 4 具有中等抑制活性。此外，唇形科植物中的倍半萜类化合物可能在属间和属内水平具有一定的化学系统学意义。
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