Chen Jian-Jun, Bai Wei, Gobu Fekadu-Roge, Wu Cheng-Hui, Zeng Jun, Sun Meng, Gao Kun
a State Key Laboratory of Applied Organic Chemistry , College of Chemistry and Chemical Engineering, Lanzhou University , Lanzhou , 730000 , China.
J Asian Nat Prod Res. 2015;17(12):1188-95. doi: 10.1080/10286020.2015.1119130. Epub 2015 Dec 16.
An unusual aromadendrane-type sesquiterpenoid with a rare hemiketal-containing 10/3 ring system, named vladimuliecin C (1), and one new eudesmane-type sesquiterpenoid, named vladimuliecin D (4), together with four known sesquiterpenoids, were isolated from the roots of Vladimiria muliensis. The structures of these compounds were elucidated by analysis of spectroscopic data. The absolute configuration of 1 was assigned by X-ray diffraction analysis. A possible biosynthetic process for the formation of 1 is proposed. Compound 1 showed moderate cytotoxicity against three human tumor cell lines.
从木里川木香（Vladimiria muliensis）的根部分离出一种具有罕见的含半缩酮10/3环系统的不寻常的芳樟烷型倍半萜，命名为川木香内酯C（1），以及一种新的桉叶烷型倍半萜，命名为川木香内酯D（4），同时还分离出四种已知的倍半萜。通过光谱数据分析阐明了这些化合物的结构。通过X射线衍射分析确定了1的绝对构型。提出了1形成的可能生物合成过程。化合物1对三种人类肿瘤细胞系显示出中等细胞毒性。
