来自云生鼠尾草（唇形科）的愈创木烷倍半萜内酯

Guaiane sesquiterpene lactones from Salvia nubicola (Lamiaceae).

作者信息

Ali Muhammad S, Ibrahim Syed A, Ahmed Shakeel, Lobkovsky Emil

机构信息

H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.

出版信息

Chem Biodivers. 2007 Jan;4(1):98-104. doi: 10.1002/cbdv.200790011.

DOI:10.1002/cbdv.200790011

PMID:17256739

Abstract

A new sesquiterpene lactone, nubiol (1), belonging to the guaiane class, along with a dimer, bisnubidiol (2), has been isolated from Salvia nubicola collected from Quetta, Pakistan. The structures of both metabolites were elucidated with the aid of spectroscopic techniques including 2D-NMR. Additionally, the structure of nubiol (1) was finally confirmed via the single crystal X-ray diffraction. Nubiol (1) was found moderately active against Pseudomonas aeruginosa.

摘要

从采自巴基斯坦奎达的紫花鼠尾草中分离出一种新的倍半萜内酯——紫花鼠尾草素（1），它属于愈创木烷类，同时还分离出了一种二聚体——双紫花鼠尾草二醇（2）。借助包括二维核磁共振在内的光谱技术阐明了这两种代谢产物的结构。此外，通过单晶X射线衍射最终确定了紫花鼠尾草素（1）的结构。发现紫花鼠尾草素（1）对铜绿假单胞菌具有中等活性。