豚鼠心脏中辣椒素敏感结构释放的P物质和降钙素基因相关肽免疫反应性可被缓激肽同时释放。
Simultaneous release by bradykinin of substance P- and calcitonin gene-related peptide immunoreactivities from capsaicin-sensitive structures in guinea-pig heart.
作者信息
Geppetti P, Maggi C A, Perretti F, Frilli S, Manzini S
机构信息
Institute of Internal Medicine and Clinical Pharmacology, University of Florence, Italy.
出版信息
Br J Pharmacol. 1988 Jun;94(2):288-90. doi: 10.1111/j.1476-5381.1988.tb11528.x.
Abstract
Both bradykinin and capsaicin infusion evoked a marked increase in the outflow of substance P- (SP-LI) and calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) from guinea-pig isolated, perfused heart. After acute exposure to capsaicin in vitro, or in hearts taken from animals pretreated in vivo with capsaicin, bradykinin failed to induce any release. The positive chronotropic effect of bradykinin was reduced after acute capsaicin administration. The effect of bradykinin in the guinea-pig heart could be mediated, at least partly, by release of neuropeptides from peripheral endings of capsaicin-sensitive sensory neurones.
摘要
缓激肽和辣椒素输注均可使豚鼠离体灌流心脏中P物质样免疫反应性（SP-LI）和降钙素基因相关肽样免疫反应性（CGRP-LI）的流出量显著增加。在体外急性暴露于辣椒素后，或在体内用辣椒素预处理的动物心脏中，缓激肽未能诱导任何释放。急性给予辣椒素后，缓激肽的正性变时作用减弱。缓激肽对豚鼠心脏的作用至少部分可由辣椒素敏感感觉神经元外周末梢释放神经肽介导。
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