类风湿关节炎的疲劳评估（采用慢性病治疗功能评估-疲劳评分）及其与疾病活动度和贫血的关系。

Assessment of fatigue in rheumatoid arthritis (by Functional Assessment of Chronic Illness Therapy-Fatigue score) and its relation to disease activity and anemia.

机构信息

From the Departments of *Medicine and †Rheumatology, PGIMS, Rohtak, Haryana, India.

出版信息

J Clin Rheumatol. 2014 Mar;20(2):87-90. doi: 10.1097/RHU.0000000000000073.

DOI:10.1097/RHU.0000000000000073

PMID:24561411

Abstract

BACKGROUND

Patients with rheumatoid arthritis (RA) mention fatigue as one of their most annoying problems. Measuring fatigue, understanding its contributory factors, and treating it as a feasible target lead to better patient outcome and improved quality of life. The Functional Assessment of Chronic Illness Therapy (FACIT) Measurement System is a collection of health-related quality-of-life questionnaires targeted to the management of chronic illness.

OBJECTIVE

The objective of this study was to evaluate fatigue using FACIT-Fatigue (FACIT-F) score and its relation to disease activity (using Disease Activity Score [DAS28] and Clinical Disease Activity Index [CDAI] score) and anemia in RA patients.

METHODS

A total of 100 RA patients were evaluated for fatigue using FACIT-F score, for disease activity using DAS28 and CDAI scores, for anemia using hemoglobin levels. Correlation studies were done using Pearson test.

RESULTS

Functional Assessment of Chronic Illness Therapy-Fatigue showed positive association with DAS28 (P < 0.001; r = -0.80) and CDAI (P < 0.001; r = -0.83). Considering various components of DAS28 and CDAI, FACIT-F showed significant correlation with tender joint count (P < 0.001; r = -0.73), swollen joint count (P < 0.001; r = -0.76), patient global assessment (P < 0.001; r = -0.72), and evaluator global assessment (P < 0.001; r = -0.75). Erythrocyte sedimentation rate had no association with the fatigue (P = 0.217). No association was observed between fatigue and hemoglobin levels (P = 0.203).

CONCLUSION

The fatigue experienced by the patients with RA is strongly associated with the severity of disease activity and is independent of anemia.

摘要

背景

类风湿关节炎（RA）患者常将疲劳感视为最恼人的问题之一。对疲劳进行评估、了解其促成因素并将其作为可行的治疗靶点，可改善患者预后并提高生活质量。慢性疾病治疗功能评估（FACIT）测量系统是一套健康相关生活质量问卷，旨在管理慢性疾病。

目的

本研究旨在使用 FACIT-Fatigue（FACIT-F）评分评估 RA 患者的疲劳，并探讨其与疾病活动度（采用疾病活动评分 28 项[DAS28]和临床疾病活动指数[CDAI]评分）和贫血的关系。

方法

共 100 例 RA 患者接受 FACIT-F 评分评估疲劳，采用 DAS28 和 CDAI 评分评估疾病活动度，采用血红蛋白水平评估贫血。采用 Pearson 检验进行相关性研究。

结果

功能性评估慢性疾病治疗-疲劳与 DAS28（P<0.001；r=-0.80）和 CDAI（P<0.001；r=-0.83）呈正相关。考虑 DAS28 和 CDAI 的各个组成部分，FACIT-F 与压痛关节数（P<0.001；r=-0.73）、肿胀关节数（P<0.001；r=-0.76）、患者总体评估（P<0.001；r=-0.72）和评估者总体评估（P<0.001；r=-0.75）显著相关。红细胞沉降率与疲劳无相关性（P=0.217）。疲劳与血红蛋白水平无相关性（P=0.203）。