银屑病和银屑病关节炎中疲劳的患病率及严重程度。
Prevalence and severity of fatigue in psoriasis and psoriatic arthritis.
作者信息
Krajewska-Włodarczyk Magdalena, Owczarczyk-Saczonek Agnieszka, Placek Waldemar
机构信息
Department of Internal Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland.
Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland.
出版信息
Postepy Dermatol Alergol. 2020 Feb;37(1):46-51. doi: 10.5114/ada.2019.83629. Epub 2020 Mar 9.
INTRODUCTION
Fatigue is an important and underrated symptom of many chronic diseases.
AIM
The evaluation of incidence and severity of fatigue as well as the influence of selected factors on fatigue in patients with psoriasis and psoriatic arthritis (PsA).
MATERIAL AND METHODS
The study included 60 patients with PsA, 58 patients with psoriasis and 61 persons in the control group aged 35-70 years. Assessment of fatigue was conducted using a fatigue subscale from the FACIT-F questionnaire. Severity of skin lesions and arthritis was determined with PASI and DAS28, respectively, as well as the number of painful and swollen joints, severity of pain and inflammatory markers.
RESULTS
Severe fatigue occurred in 17%, 28%, and 1.6% of patients with psoriasis, PsA and the control group, respectively. Severity of fatigue was significantly higher in patients with PsA as compared to patients with psoriasis ( < 0.0001). In patients with psoriasis and PsA, it decreased along with the duration of psoriasis ( = 0.291, < 0.05 vs. = 0.382, < 0.05, respectively). No significant correlation was found between the duration of PsA and fatigue. After using the linear regression model, severity of fatigue in psoriasis was correlated with the age of patients and the duration of psoriasis, while in PsA, with the duration of psoriasis, PASI, DAS28, CRP and the number of painful joints.
CONCLUSIONS
The results of this study may indicate the need for routine fatigue examination among people with psoriasis and psoriatic arthritis.
引言
疲劳是许多慢性疾病中一种重要但被低估的症状。
目的
评估银屑病和银屑病关节炎（PsA）患者疲劳的发生率、严重程度以及某些选定因素对疲劳的影响。
材料与方法
该研究纳入了60例PsA患者、58例银屑病患者以及61名年龄在35至70岁之间的对照组人员。使用FACIT-F问卷中的疲劳分量表对疲劳进行评估。分别用银屑病面积和严重程度指数（PASI）及28个关节疾病活动度评分（DAS28）来确定皮肤病变和关节炎的严重程度，同时确定疼痛和肿胀关节的数量、疼痛严重程度及炎症标志物。
结果
银屑病患者、PsA患者和对照组中出现严重疲劳的比例分别为17%、28%和1.6%。与银屑病患者相比，PsA患者的疲劳严重程度显著更高（<0.0001）。在银屑病和PsA患者中，疲劳严重程度随银屑病病程延长而降低（分别为=0.291，<0.05；=0.382，<0.05）。未发现PsA病程与疲劳之间存在显著相关性。使用线性回归模型后，银屑病患者的疲劳严重程度与患者年龄和银屑病病程相关，而在PsA患者中，与银屑病病程、PASI、DAS28、C反应蛋白（CRP）及疼痛关节数量相关。
结论
本研究结果可能表明银屑病和银屑病关节炎患者需要进行常规疲劳检查。
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