Division of General Internal Medicine, Geriatrics, and Palliative Care, Department of Medicine, University of Virginia, PO Box 800744, Charlottesville, VA, 22908, USA,
Support Care Cancer. 2014 Jul;22(7):1883-8. doi: 10.1007/s00520-014-2167-6. Epub 2014 Feb 23.
The use of opioids for management of cancer-related pain has increased significantly and has been associated with a substantial rise in rates of substance abuse and diversion. There is a paucity of data not only on the prevalence of substance abuse in cancer patients, but also for issues of drug use and diversion in family caregivers. This study aimed to evaluate the frequency of risk factors for substance abuse and diversion, and abnormal urine drug screens in cancer patients receiving palliative care.
A retrospective chart review was performed for patients with cancer who were seen in the University of Virginia Palliative Care Clinic during the month of September 2012. We evaluated Opioid Risk Tool variables and total scores, insurance status, and urine drug screen results.
Of the 114 cancer patients seen in September 2012, the mean Opioid Risk Tool score was 3.79, with 43% of patients defined as medium to high risk. Age (16-45 years old, 23%) and a personal history of alcohol (23%) or illicit drugs (21%) were the most common risk factors identified. We obtained a urine drug screen on 40% of patients, noting abnormal findings in 45.65%.
Opioids are an effective treatment for cancer-related pain, yet substantial risk for substance abuse exits in the cancer population. Screening tools, such as the Opioid Risk Tool, should be used as part of a complete patient assessment to balance risk with appropriate relief of suffering.
阿片类药物在癌症相关疼痛管理中的应用显著增加,与物质滥用和药物转用率的大幅上升有关。不仅缺乏癌症患者物质滥用的流行率数据,而且缺乏家庭护理者药物使用和转用问题的数据。本研究旨在评估接受姑息治疗的癌症患者物质滥用和药物转用的风险因素以及异常尿液药物筛查的频率。
对 2012 年 9 月在弗吉尼亚大学姑息治疗诊所就诊的癌症患者进行回顾性图表审查。我们评估了阿片类药物风险工具变量和总评分、保险状况和尿液药物筛查结果。
在 2012 年 9 月就诊的 114 例癌症患者中,阿片类药物风险工具评分的平均值为 3.79,43%的患者被定义为中高危。年龄(16-45 岁,23%)和酒精(23%)或非法药物(21%)个人史是最常见的风险因素。我们对 40%的患者进行了尿液药物筛查,发现异常结果占 45.65%。
阿片类药物是治疗癌症相关疼痛的有效方法,但癌症患者存在大量物质滥用的风险。阿片类药物风险工具等筛查工具应作为完整患者评估的一部分,在适当缓解痛苦的同时平衡风险。