Huang Qiao-Juan, Guo Yuan-Lin, Zhu Cheng-Gang, Qing Ping, Xu Rui-Xia, Wu Na-Qiong, Jiang Li-Xin, Chen Meng-Hua, Li Jian-Jun
Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing , P. R. China.
Scand J Clin Lab Invest. 2014 Apr;74(3):228-34. doi: 10.3109/00365513.2013.878030. Epub 2014 Feb 24.
It has been shown that alkaline phosphatase (ALP) is a reliable marker for cardiovascular events and mortality. However, there is no data available regarding the association of ALP with isolated coronary artery ectasia (CAE). The aim of the present study was to assess the serum ALP activity in isolated CAE.
Seventy-nine patients with isolated CAE (59 males; mean age, 52 ± 12 years) and 88 age- and gender-matched normal subjects (73 males; mean age, 52 ± 7 years) were enrolled. Baseline characteristics were recorded in both groups and serum ALP activity were compared between the two groups.
Patients with angiography-proved isolated CAE had significantly higher serum ALP activity compared with angiographic normal controls (72.41 ± 29.97 vs. 59.27 ± 14.46, p < 0.001). In the multivariate analysis, increased ALP (OR = 1.037, 95% CI 1.017-1.057, p < 0.001) were independent predictors for the presence of isolated CAE. A cut-off of ≥ 66.5 U/L of ALP activity measured on admission had a 60.8% sensitivity and 75.0% specificity in predicting isolated CAE by receiver operating characteristic (ROC) curve analysis.
Our data firstly demonstrated that serum ALP activity, a readily available clinical laboratory value, was associated with the presence of isolated CAE.
已有研究表明碱性磷酸酶（ALP）是心血管事件和死亡率的可靠标志物。然而，关于ALP与孤立性冠状动脉扩张（CAE）之间的关联尚无相关数据。本研究的目的是评估孤立性CAE患者的血清ALP活性。
纳入79例孤立性CAE患者（男性59例；平均年龄52±12岁）和88例年龄及性别匹配的正常受试者（男性73例；平均年龄52±7岁）。记录两组的基线特征，并比较两组的血清ALP活性。
血管造影证实的孤立性CAE患者的血清ALP活性显著高于血管造影正常对照组（72.41±29.97对59.27±14.46，p<0.001）。在多变量分析中，ALP升高（OR=1.037，95%CI 1.017-1.057，p<0.001）是孤立性CAE存在的独立预测因素。入院时测量的ALP活性≥66.5 U/L的临界值在通过受试者工作特征（ROC）曲线分析预测孤立性CAE时具有60.8%的敏感性和75.0%的特异性。
我们的数据首次表明，血清ALP活性这一易于获得的临床实验室值与孤立性CAE的存在相关。
