1 Clinical Nutrition, Vidarium Research Group, Nutrition, Health and Wellness Research Center, Nutresa Business Group (Grupo Empresarial Nutresa) , Medellín, Colombia .
Metab Syndr Relat Disord. 2014 May;12(4):202-9. doi: 10.1089/met.2013.0127. Epub 2014 Feb 24.
Despite the increasing prevalence of metabolic syndrome in adolescents, there is no consensus for its diagnosis.
A cross-sectional study was conducted to compare the prevalence of metabolic syndrome in adolescents by different definitions, evaluate their concordance, and suggest which definition to apply in this population. A total of 851 adolescents between 10 and 18 years of age were evaluated. Anthropometric (weight, height, waist circumference), biochemical (glucose, lipid profile), and blood pressure data were taken. The prevalence of metabolic syndrome was determined by the definitions of the International Diabetes Federation (IDF) and four published studies by Cook et al., de Ferranti et al., Agudelo et al., and Ford et al. Concordance was determined according to the kappa index.
The prevalence of metabolic syndrome was 0.9%, 3.8%, 4.1%, 10.5%, and 11.4%, according to the IDF, Cook et al., Ford et al., Agudelo et al., and de Ferranti et al. definitions, respectively. The most prevalent components were hypertriglyceridemia and low high-density lipoprotein cholesterol, whereas the least prevalent components were abdominal obesity and hyperglycemia. The highest concordance was found between the definitions by Cook et al. and Ford et al. (kappa=0.92), whereas the greatest discordance was between the de Ferranti et al. and IDF definitions (kappa=0.14).
Metabolic syndrome and its components were conditions present in the adolescents of this study. In this population, with a high prevalence of dyslipidemia and a lower prevalence of abdominal obesity and hyperglycemia, the recommendation to diagnose metabolic syndrome would be that used by Ford et al.
尽管青少年代谢综合征的患病率不断增加，但目前仍未达成其诊断标准的共识。
本研究采用横断面研究的方法，比较了不同定义下青少年代谢综合征的患病率，评估其一致性，并提出在该人群中适用的定义。共纳入 851 名年龄在 10 至 18 岁之间的青少年。测量了他们的人体测量学（体重、身高、腰围）、生化（血糖、血脂谱）和血压数据。代谢综合征的患病率通过国际糖尿病联合会（IDF）和 Cook 等人、de Ferranti 等人、Agudelo 等人以及 Ford 等人发表的四项研究的定义来确定。一致性根据 Kappa 指数来确定。
根据 IDF、Cook 等人、Ford 等人、Agudelo 等人和 de Ferranti 等人的定义，代谢综合征的患病率分别为 0.9%、3.8%、4.1%、10.5%和 11.4%。最常见的代谢综合征组分是高三酰甘油血症和低高密度脂蛋白胆固醇血症，而最不常见的组分是腹型肥胖和高血糖症。Cook 等人和 Ford 等人的定义之间的一致性最高（Kappa=0.92），而 de Ferranti 等人和 IDF 定义之间的一致性最低（Kappa=0.14）。
本研究中的青少年存在代谢综合征及其组分。在该人群中，血脂异常的患病率较高，腹型肥胖和高血糖症的患病率较低，建议采用 Ford 等人提出的定义来诊断代谢综合征。
