Laboratory of Food Chemistry and Nutrition Science, Institute of Agro-Products Processing Science and Technology, Chinese Academy of Agricultural Sciences; Key Laboratory of Agro-products Processing, Ministry of Agriculture, 2 Yuan Ming Yuan West Road, Haidian District, Beijing 100193, People's Republic of China.
J Agric Food Chem. 2014 Mar 19;62(11):2364-73. doi: 10.1021/jf405032f. Epub 2014 Mar 5.
This study aimed to investigate the dealcoholic effect and preventive effect of anthocyanins from purple sweet potato (PSPAs) on acute and subacute alcoholic liver damage (ALD). Seven-week-old male inbred mice were grouped into five groups: control group (without PSPAs and ethanol treatments), model group (with ethanol treatment only), low-dose group (50 mg PSPAs/kg body weight), middle-dose group (125 mg PSPAs/kg body weight), and high-dose group (375 mg PSPAs/kg body weight), and the mice in all groups were administered intragastrically. Biochemical parameters of serum and liver were determined, and the histopathological changes of liver tissue were also analyzed. Results showed that all tested parameters were ameliorated after consumption of PSPAs. Therefore, PSPAs have preventive effect on acute and subacute ALD. It is suggested that PSPAs could be used as a supplementary reagent during prophylactic and curative managements of ALD.
本研究旨在探讨紫薯花色苷（PSPA）的去酒精作用及其对急性和亚急性酒精性肝损伤（ALD）的预防作用。将 7 周龄雄性近交系小鼠分为五组：对照组（无 PSPA 和乙醇处理）、模型组（仅用乙醇处理）、低剂量组（50mg PSPA/kg 体重）、中剂量组（125mg PSPA/kg 体重）和高剂量组（375mg PSPA/kg 体重），所有组均通过灌胃给药。测定血清和肝脏的生化参数，并分析肝组织的组织病理学变化。结果表明，PSPA 摄入后所有测试参数均得到改善。因此，PSPA 对急性和亚急性 ALD 具有预防作用。提示 PSPA 可作为 ALD 预防性和治疗性管理的辅助试剂。
