花青素通过抑制促炎信号传导减轻酒精诱导的肝损伤。

Anthocyanins attenuate alcohol-induced hepatic injury by inhibiting pro-inflammation signalling.

作者信息

Jiang Zhihui, Chen Chen, Xie Wenyan, Wang Meng, Wang Jian, Zhang Xiaoying

机构信息

a College of Veterinary Medicine, Northwest A&F University , Yangling , Shaanxi 712100 , P.R. China.

b School of Biological Science and Engineering, Shaanxi University of Technology , Hanzhong , Shaanxi 723001 , P.R. China.

出版信息

Nat Prod Res. 2016;30(4):469-73. doi: 10.1080/14786419.2015.1020492. Epub 2015 Mar 16.

DOI:10.1080/14786419.2015.1020492

PMID:25774691

Abstract

We assessed phytochemical components of anthocyanins from purple sweet potato (PSP) and purple potato (PP) with UPLC-MS/MS, and investigated their inhibitory effect on inflammatory response in alcoholic liver disease (ALD). Results showed that serum AST and ALT levels in PP anthocyanins (PPAs) and PSP anthocyanins (PSPAs) treatments were lower than those of alcohol-treated group. PPAs and PSPAs could inhibit mRNA expressions of inflammatory factors (TNF-α, VCAM-1, IFN-γ and CXCL-1). The mRNA levels of NF-κB, STAT, and TLR in PPAs and PSPAs treatment groups were lower than in alcohol treatment group. Our results indicate that PP and PSP are good source of anti-inflammatory anthocyanins to prevent ALD.

摘要

我们使用超高效液相色谱-串联质谱法（UPLC-MS/MS）评估了紫薯（PSP）和紫土豆（PP）中花青素的植物化学成分，并研究了它们对酒精性肝病（ALD）炎症反应的抑制作用。结果表明，PP花青素（PPAs）和PSP花青素（PSPAs）处理组的血清谷草转氨酶（AST）和谷丙转氨酶（ALT）水平低于酒精处理组。PPAs和PSPAs可抑制炎症因子（TNF-α、VCAM-1、IFN-γ和CXCL-1）的mRNA表达。PPAs和PSPAs处理组中核因子κB（NF-κB）、信号转导和转录激活因子（STAT）以及Toll样受体（TLR）的mRNA水平低于酒精处理组。我们的结果表明，PP和PSP是预防ALD的抗炎花青素的良好来源。