CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China.
Nanoscale. 2014 Apr 7;6(7):3670-8. doi: 10.1039/c3nr06841b.
Due to aspect ratio dependent localized surface plasmon resonance (SPR), gold nanorods (Au NRs) can be tuned to have a strong absorption in the near infrared region (NIR) and convert light to heat energy, which shows promises in cancer photothermal therapy. In this study, we introduced another more efficient NIR photothermal agent, Au nanorods coated with a shell of Pt nanodots (Au@Pt nanostructures). After surface modification with Pt dots, the Au@Pt nanostructure became a more efficient photothermal therapy agent as verified both in vitro and in vivo. To clarify the mechanism, we assessed the interaction between the MDA-MB-231 cells with Au@Pt or Au NRs. Results showed that the slightly higher uptake and the reduced sensitivity of the longitudinal SPR band on the intracellular aggregate state may contribute to the better photothermal efficiency for Au@Pt NRs. The theoretical studies further confirmed that the Au@Pt nanostructure itself exhibited better photothermal efficiency compared to Au NRs. These advantages make the Au@Pt nanostructure a more attractive and effective agent for cancer photothermal therapy than general Au NRs.
由于纵横比依赖的局域表面等离子体共振（SPR），金纳米棒（Au NRs）可以被调谐到近红外区域（NIR）具有很强的吸收，并将光转化为热能，这在癌症光热治疗中显示出了前景。在这项研究中，我们引入了另一种更有效的 NIR 光热试剂，即金纳米棒表面覆盖一层 Pt 纳米点（Au@Pt 纳米结构）。经过 Pt 点的表面修饰，Au@Pt 纳米结构成为一种更有效的光热治疗试剂，这在体外和体内都得到了验证。为了阐明机制，我们评估了 MDA-MB-231 细胞与 Au@Pt 或 Au NRs 的相互作用。结果表明，细胞内聚集体状态下稍高的摄取量和纵向 SPR 带的敏感性降低可能有助于 Au@Pt NRs 更好的光热效率。理论研究进一步证实，与 Au NRs 相比，Au@Pt 纳米结构本身表现出更好的光热效率。这些优势使得 Au@Pt 纳米结构成为一种比普通 Au NRs 更有吸引力和有效的癌症光热治疗试剂。
