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生长期脱发再探。

Telogen effluvium revisited.

机构信息

University of Genoa, Genoa, Italy -

出版信息

G Ital Dermatol Venereol. 2014 Feb;149(1):47-54.

PMID:24566565
Abstract

Telogen effluvium (TE) is heterogeneous disorder. It can be classified into three main categories: the premature teloptosis, the collective teloptosis and the premature entry into telogen. The last category can be divided in three types: the drug induced TE, TE due to dietary deficiencies and the "autoimmune" TE. Despite this heterogeneity, the large majority of TE that arrive at the dermatologist's observation pertain to the autoimmune type, featuring a standard presentation. The typical patient is a woman claiming to have always had a "full head of hair" and reporting her hair to come out suddenly "by the handful". Usually, she is accurate about the date of onset of her shedding. She is in good health, without signs of anorexia nor nutrient deficiencies. She admits to having been in an anxious state for some months, and felt, occasionally or not, a painful or burning sensation at the scalp (trichodynia). Usually, the course of the disorder is chronic but intermittent, with apparent remissions being irregularly intermitted by relapses. The shed hairs do not exhibit telogen roots, but mostly exogen ones. This distinct entity, shares some analogies with alopecia areata, including the triggering role of emotional stress, trichodynia and the frequent association with Hashimoto's thyroiditis. Methods to assess its severity and to monitor treatment are described. In the absence of a documented etiopathogenesis, no treatment can be endorsed, but a course of topical corticosteroids could be tried.

摘要

休止期脱发(TE)是一种异质性疾病。它可以分为三大类:过早休止期、集体休止期和过早进入休止期。后一类又可分为三种类型:药物引起的 TE、因饮食缺乏引起的 TE 和“自身免疫性”TE。尽管存在这种异质性,但绝大多数到达皮肤科医生观察的 TE 都属于自身免疫性类型,具有标准的表现。典型患者是一位女性,她声称自己一直“满头秀发”,并报告说她的头发突然“一把一把地掉”。通常,她对脱发开始的日期很准确。她身体健康,没有厌食或营养缺乏的迹象。她承认自己已经有几个月处于焦虑状态,偶尔或不时感到头皮疼痛或烧灼感(脱发性头痛)。通常,这种疾病的病程是慢性的,但间歇性的,明显的缓解期不规则地被复发所打断。脱落的毛发没有休止期的根,大多是外生的。这种独特的实体与斑秃有一些相似之处,包括情绪压力、脱发性头痛和桥本甲状腺炎的频繁关联的触发作用。描述了评估其严重程度和监测治疗的方法。由于缺乏明确的病因发病机制,不能推荐任何治疗方法,但可以尝试局部皮质类固醇治疗。

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Telogen effluvium revisited.生长期脱发再探。
G Ital Dermatol Venereol. 2014 Feb;149(1):47-54.
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Sequential cyclic changes of hair roots revealed by dermoscopy demonstrate a progressive mechanism of diffuse alopecia areata over time.皮肤镜检查所揭示的毛根连续周期性变化表明,随着时间推移,斑秃呈进行性发展机制。
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Diagnosis and management of the hair loss patient.脱发患者的诊断与管理
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Patients with profuse hair shedding may reveal anagen hair dystrophy: a diagnostic clue of alopecia areata incognita.大量脱发的患者可能存在生长期毛发营养不良:这是未知型斑秃的一个诊断线索。
J Eur Acad Dermatol Venereol. 2011 Jul;25(7):808-10. doi: 10.1111/j.1468-3083.2010.03869.x. Epub 2010 Oct 15.
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'Atrophic telogen effluvium' from cytotoxic drugs and a randomized controlled trial to investigate the possible protective effect of pretreatment with a topical vitamin D analogue in humans.细胞毒性药物所致的“萎缩性休止期脱发”以及一项关于研究局部应用维生素D类似物预处理对人类可能的保护作用的随机对照试验。
Br J Dermatol. 2005 Jul;153(1):103-12. doi: 10.1111/j.1365-2133.2005.06608.x.
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Dermatol Clin. 2013 Oct;31(4):695-708, x. doi: 10.1016/j.det.2013.06.007.
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Telogen Effluvium - a review of the science and current obstacles.休止期脱发:科学综述与当前障碍
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Alopecia in women.女性脱发
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[Hair diseases in childhood].[儿童期毛发疾病]
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Curr Drug Discov Technol. 2024;21(2):e200723218949. doi: 10.2174/1570163820666230720153607.
2
Dermatologic manifestations of thyroid disease: a literature review.甲状腺疾病的皮肤表现:文献综述。
Front Endocrinol (Lausanne). 2023 May 12;14:1167890. doi: 10.3389/fendo.2023.1167890. eCollection 2023.
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Study of the Thyroid Profile of Patients with Alopecia.斑秃患者甲状腺状况的研究。
J Clin Med. 2023 Jan 31;12(3):1115. doi: 10.3390/jcm12031115.
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t-Flavanone Improves the Male Pattern of Hair Loss by Enhancing Hair-Anchoring Strength: A Randomized, Double-Blind, Placebo-Controlled Study.木犀草素通过增强头发锚固力改善男性型脱发:一项随机、双盲、安慰剂对照研究。
Dermatol Ther (Heidelb). 2016 Mar;6(1):59-68. doi: 10.1007/s13555-016-0101-1. Epub 2016 Feb 20.
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Drug discovery for alopecia: gone today, hair tomorrow.斑秃的药物研发:今日尚无药,明日新发长。
Expert Opin Drug Discov. 2015 Mar;10(3):269-92. doi: 10.1517/17460441.2015.1009892. Epub 2015 Feb 9.