University of Genoa, Genoa, Italy -
G Ital Dermatol Venereol. 2014 Feb;149(1):47-54.
Telogen effluvium (TE) is heterogeneous disorder. It can be classified into three main categories: the premature teloptosis, the collective teloptosis and the premature entry into telogen. The last category can be divided in three types: the drug induced TE, TE due to dietary deficiencies and the "autoimmune" TE. Despite this heterogeneity, the large majority of TE that arrive at the dermatologist's observation pertain to the autoimmune type, featuring a standard presentation. The typical patient is a woman claiming to have always had a "full head of hair" and reporting her hair to come out suddenly "by the handful". Usually, she is accurate about the date of onset of her shedding. She is in good health, without signs of anorexia nor nutrient deficiencies. She admits to having been in an anxious state for some months, and felt, occasionally or not, a painful or burning sensation at the scalp (trichodynia). Usually, the course of the disorder is chronic but intermittent, with apparent remissions being irregularly intermitted by relapses. The shed hairs do not exhibit telogen roots, but mostly exogen ones. This distinct entity, shares some analogies with alopecia areata, including the triggering role of emotional stress, trichodynia and the frequent association with Hashimoto's thyroiditis. Methods to assess its severity and to monitor treatment are described. In the absence of a documented etiopathogenesis, no treatment can be endorsed, but a course of topical corticosteroids could be tried.
休止期脱发(TE)是一种异质性疾病。它可以分为三大类:过早休止期、集体休止期和过早进入休止期。后一类又可分为三种类型:药物引起的 TE、因饮食缺乏引起的 TE 和“自身免疫性”TE。尽管存在这种异质性,但绝大多数到达皮肤科医生观察的 TE 都属于自身免疫性类型,具有标准的表现。典型患者是一位女性,她声称自己一直“满头秀发”,并报告说她的头发突然“一把一把地掉”。通常,她对脱发开始的日期很准确。她身体健康,没有厌食或营养缺乏的迹象。她承认自己已经有几个月处于焦虑状态,偶尔或不时感到头皮疼痛或烧灼感(脱发性头痛)。通常,这种疾病的病程是慢性的,但间歇性的,明显的缓解期不规则地被复发所打断。脱落的毛发没有休止期的根,大多是外生的。这种独特的实体与斑秃有一些相似之处,包括情绪压力、脱发性头痛和桥本甲状腺炎的频繁关联的触发作用。描述了评估其严重程度和监测治疗的方法。由于缺乏明确的病因发病机制,不能推荐任何治疗方法,但可以尝试局部皮质类固醇治疗。