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甲状腺疾病的皮肤表现:文献综述。

Dermatologic manifestations of thyroid disease: a literature review.

机构信息

Department of Endocrinology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, United States.

出版信息

Front Endocrinol (Lausanne). 2023 May 12;14:1167890. doi: 10.3389/fendo.2023.1167890. eCollection 2023.


DOI:10.3389/fendo.2023.1167890
PMID:37251685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10214500/
Abstract

INTRODUCTION: Thyroid hormone is considered one of the key regulatory hormones for skin homeostasis. Multiple organs are affected by the release of peripheral thyroid hormones (T4 and T3) further regulating various functions at a cellular level. Specifically, skin is considered an important target organ in which the thyroid hormone has a significant impact. Multiple skin diseases are associated with thyroid hormone dysregulation. However, other striking dermatologic manifestations are seen in nails and hair as well. Hypothyroidism, hyperthyroidism, and thyroid cancer can have an array of cutaneous manifestations, and we present the recent updates in this field. METHODS: A PubMed search was performed for updates in any new skin disease findings and treatments between 2010 and 2022. Research published in the past decade and previously known foundational skin findings associated with thyroid disease were presented in this review. CONCLUSION: Cutaneous manifestations of thyroid disease is one of the first notable signs of thyroid hormone dysregulation. This article reviews the recent updates on the thyroid and skin interplay, and it further discusses overt visible findings and various available treatment modalities.

摘要

简介:甲状腺激素被认为是皮肤内稳态的关键调节激素之一。外周甲状腺激素(T4 和 T3)的释放会影响多个器官,进一步在细胞水平上调节各种功能。具体来说,皮肤被认为是甲状腺激素具有重大影响的重要靶器官。多种皮肤疾病与甲状腺激素失调有关。然而,在指甲和头发上也能看到其他显著的皮肤表现。甲状腺功能减退症、甲状腺功能亢进症和甲状腺癌可能有一系列的皮肤表现,我们将介绍该领域的最新进展。

方法:对 2010 年至 2022 年期间有关任何新的皮肤疾病发现和治疗的更新内容进行了 PubMed 搜索。本综述介绍了过去十年发表的研究以及以前已知的与甲状腺疾病相关的基础皮肤发现。

结论:甲状腺疾病的皮肤表现是甲状腺激素失调的最初明显迹象之一。本文综述了甲状腺与皮肤相互作用的最新进展,并进一步讨论了明显的可见表现和各种可用的治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d76/10214500/7c70eadf075d/fendo-14-1167890-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d76/10214500/4461a4834802/fendo-14-1167890-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d76/10214500/46c192f13d84/fendo-14-1167890-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d76/10214500/8bb617bfe721/fendo-14-1167890-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d76/10214500/59da270ebc73/fendo-14-1167890-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d76/10214500/b4d2a3dcd2f2/fendo-14-1167890-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d76/10214500/3f6adb289e0f/fendo-14-1167890-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d76/10214500/ae54a3197888/fendo-14-1167890-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d76/10214500/41498976af81/fendo-14-1167890-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d76/10214500/547033b2572a/fendo-14-1167890-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d76/10214500/934f3a83147b/fendo-14-1167890-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d76/10214500/e893e1fc461a/fendo-14-1167890-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d76/10214500/543c415e60e5/fendo-14-1167890-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d76/10214500/7c70eadf075d/fendo-14-1167890-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d76/10214500/4461a4834802/fendo-14-1167890-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d76/10214500/46c192f13d84/fendo-14-1167890-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d76/10214500/8bb617bfe721/fendo-14-1167890-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d76/10214500/59da270ebc73/fendo-14-1167890-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d76/10214500/b4d2a3dcd2f2/fendo-14-1167890-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d76/10214500/3f6adb289e0f/fendo-14-1167890-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d76/10214500/ae54a3197888/fendo-14-1167890-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d76/10214500/41498976af81/fendo-14-1167890-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d76/10214500/547033b2572a/fendo-14-1167890-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d76/10214500/934f3a83147b/fendo-14-1167890-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d76/10214500/e893e1fc461a/fendo-14-1167890-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d76/10214500/543c415e60e5/fendo-14-1167890-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d76/10214500/7c70eadf075d/fendo-14-1167890-g013.jpg

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[1]
Study of the Thyroid Profile of Patients with Alopecia.

J Clin Med. 2023-1-31

[2]
Thyroid Dermopathy and Acropachy.

Mayo Clin Proc. 2022-12

[3]
Graves' disease complicated by concurrent thyroid eye disease and pretibial myxedema successfully treated with teprotumumab.

Clin Case Rep. 2022-11-19

[4]
Nail Changes Associated With Thyroid Disease.

Cutis. 2022-8

[5]
De Novo Appearance of Pre-Tibial Myxedema After Radioactive Iodine Therapy for Graves' Disease.

Indian J Endocrinol Metab. 2022

[6]
Urticarial vasculitis in a young woman with Graves hyperthyroidism.

CMAJ. 2022-5-2

[7]
Alopecia Universalis Associated with Hyperthyroidism Treated with Azathioprine and Hydroxychloroquine: A Case Report.

JNMA J Nepal Med Assoc. 2021-9-11

[8]
Dermatologic Manifestations of Endocrine Disorders.

Cureus. 2021-9-27

[9]
Terry's nails sign in a girl with autoimmune hypothyroidism and familial hyper-CK-emia.

Int J Dermatol. 2022-7

[10]
Henoch-Schönlein Purpura (IgA Vasculitis) in Association with Thyrotoxicosis.

Case Rep Endocrinol. 2021-5-22

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