Department of Pharmacy, Pranveer Singh Institute of Technology (Pharmacy) NH19 Bhaunti Kanpur, India.
Curr Drug Discov Technol. 2024;21(2):e200723218949. doi: 10.2174/1570163820666230720153607.
Nowadays, the majority of the population suffers from the problem of hair loss. It leads to disturbed mental health, lower self-confidence, and a lot more problems. A lot of the hair loss therapies available are not reliable and lead to recurrence and side effects after some time. Cannabinoids (CBD) have recently become quite popular for their benefits against hair loss. CBD oil preparations have been used both internally and externally for oral and topical use, respectively. Due to the presence of the endocannabinoid system (ECS) in the body, which naturally targets CB1 and CB2 receptors, the control of hair fall is possible. CBD is used topically for hair loss, whereas it is administered orally for the treatment and management of a medical condition, i.e., alopecia.
AIM/OBJECTIVE: The present review aimed to provide an in-depth study on hair loss and its management using CBD and its associated mechanisms.
Electronic databases, such as ScienceDirect, Google Scholar, PubMed, Wiley, Springer, and Scopus, were thoroughly searched for information about how CBD is used, how it works, and what role it plays in treating alopecia and hair loss.
This review has highlighted the use of CBD-based hair loss therapy, and described various types of hair loss and their treatments. This review also details the phytocannabinoids and the potential mechanisms of CBD's activity against hair loss and alopecia.
The data obtained from the literature regarding CBD and hair loss provide a scientific basis for CBD use in alopecia. Additionally, a more precise and comprehensive study concerning CBD needs to be carried out at the pre-clinical and clinical levels.
如今，大多数人都受到脱发问题的困扰。这导致精神健康受到干扰、自信心降低，以及更多的问题。现有的许多脱发疗法不可靠，一段时间后会复发并产生副作用。大麻素（CBD）因其对脱发的益处而最近变得非常流行。CBD 油制剂分别已被用于内部和外部，以进行口服和局部使用。由于体内存在内源性大麻素系统（ECS），它自然靶向 CB1 和 CB2 受体，因此可以控制脱发。CBD 被用于脱发的局部治疗，而用于治疗和管理脱发症等医学病症时则口服使用。
本综述旨在深入研究使用 CBD 治疗脱发及其相关机制。
通过电子数据库（如 ScienceDirect、Google Scholar、PubMed、Wiley、Springer 和 Scopus）全面搜索有关 CBD 的使用方式、作用机制以及在治疗脱发和脱发症中的作用的信息。
本综述强调了基于 CBD 的脱发治疗方法，并描述了各种类型的脱发及其治疗方法。本综述还详细介绍了植物大麻素和 CBD 对抗脱发和脱发症的潜在作用机制。
文献中关于 CBD 和脱发的数据为 CBD 在脱发症中的应用提供了科学依据。此外，需要在临床前和临床水平上对 CBD 进行更精确和全面的研究。
