Knoblach Barbara, Rachubinski Richard A
Department of Cell Biology; University of Alberta; Edmonton, AB Canada.
Commun Integr Biol. 2013 Nov 1;6(6):e26901. doi: 10.4161/cib.26901. Epub 2013 Nov 13.
The formation of membrane contact sites between cellular organelles is required for proper organelle communication and maintenance in the compartmentalized eukaryotic cell. We recently identified a tether that links peroxisomes to the cortical ER in the yeast, Saccharomyces cerevisiae. The tether is made up of the peroxisome biogenic protein Pex3p and the peroxisome inheritance factor Inp1p, and is formed by Inp1p-mediated linkage of ER-bound Pex3p and peroxisomal Pex3p. Here we discuss how this tether is fine-tuned to ensure that peroxisomes are stably maintained over generations of yeast cells.
在真核细胞的区室化结构中，细胞器之间形成膜接触位点对于细胞器间的正常通讯和维持是必需的。我们最近在酿酒酵母中鉴定出一种将过氧化物酶体与皮质内质网连接起来的栓系蛋白。该栓系蛋白由过氧化物酶体生物发生蛋白Pex3p和过氧化物酶体遗传因子Inp1p组成，是由Inp1p介导的内质网结合的Pex3p与过氧化物酶体Pex3p之间的连接形成的。在此，我们讨论这种栓系蛋白是如何进行微调以确保过氧化物酶体在酵母细胞的世代中得以稳定维持的。
