Department of Cell Biology, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada.
Nat Rev Mol Cell Biol. 2010 Sep;11(9):644-54. doi: 10.1038/nrm2960. Epub 2010 Aug 18.
Preserving a functional set of cytoplasmic organelles in a eukaryotic cell requires a process of accurate organelle inheritance at cell division. Studies of peroxisome inheritance in yeast have revealed that polarized transport of a subset of peroxisomes to the emergent daughter cell is balanced by retention mechanisms operating in both mother cell and bud to achieve an equitable distribution of peroxisomes between them. It is becoming apparent that some common mechanistic principles apply to the inheritance of all organelles, but at the same time, inheritance factors specific for each organelle type allow the cell to differentially and specifically control the inheritance of its different organelle populations.
在真核细胞中，保持一组功能正常的细胞质细胞器需要在细胞分裂时进行精确的细胞器遗传过程。对酵母中过氧化物酶体遗传的研究表明，一组过氧化物酶体向新生子细胞的极化运输被母细胞和芽中起作用的保留机制所平衡，以实现过氧化物酶体在它们之间的公平分配。现在越来越明显的是，一些共同的机械原则适用于所有细胞器的遗传，但同时，每种细胞器类型特有的遗传因子允许细胞对其不同细胞器群体的遗传进行有差异和特异性的控制。
