土耳其首例输入性球孢子菌病：对非流行地区实验室工作人员的潜在健康风险。

First imported coccidioidomycosis in Turkey: A potential health risk for laboratory workers outside endemic areas.

作者信息

Kantarcioglu A Serda, Sandoval-Denis M, Aygun Gokhan, Kiraz Nuri, Akman Canan, Apaydin Hulya, Karaman Emin, Guarro Josep, de Hoog G Sybren, Gurel M S

机构信息

Cerrahpasa Medical Faculty, Department of Medical Microbiology, Deep Mycosis Laboratory, Istanbul University, Istanbul 34098, Turkey.

Unitat de Microbiologia, Facultat de Medicina i Ciencies de la Salut, IISPV, Universitat Rovira i Virgili, 43201 Reus, Spain.

出版信息

Med Mycol Case Rep. 2014 Jan 20;3:20-5. doi: 10.1016/j.mmcr.2014.01.002. eCollection 2014 Jan.

DOI:10.1016/j.mmcr.2014.01.002

PMID:24567896

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3930961/

Abstract

Coccidioidomycosis caused by Coccidioides immitis or Coccidioides posadasii is endemic in arid climate zones in America, travel-related cases have been reported. We report the first documented case of coccidioidomycosis in Turkey, overviewing reported cases in Europe and underlying difficulties of differential diagnosis outside endemic regions. The patient was an otherwise healthy 41-year-old man who travelled endemic areas. Laboratory diagnosis was based on direct microscopy of two subsequent subcutaneous biopsy specimens and culture and confirmed molecularly. Laboratory personnel should become aware that BioSafety Level-3 organisms may become more frequent and widespread.

摘要

由粗球孢子菌或波萨达斯球孢子菌引起的球孢子菌病在美国干旱气候区为地方病，已有与旅行相关的病例报道。我们报告了土耳其首例有记录的球孢子菌病病例，概述了欧洲报告的病例以及在非流行地区进行鉴别诊断的潜在困难。患者是一名41岁的健康男性，曾前往流行地区。实验室诊断基于对两份后续皮下活检标本的直接显微镜检查、培养，并通过分子学方法得以确诊。实验室工作人员应意识到生物安全3级病原体可能会变得更加常见和广泛传播。