Vayghan Hamed Jafari, Ghadimi Sevda Saleh, Nourazarian Ali Reza
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran E-mail :
Asian Pac J Cancer Prev. 2014;15(2):585-8. doi: 10.7314/apjcp.2014.15.2.585.
Colorectal cancer is one of the most prevalent diseases all over the world. Early screening and start of chemotherapy is effective in decreasing mortality. This type of cancer can be controlled to some extent via a healthy diet rich in fruit and vegetables. Ginseng is a plant which has been consumed as a herbal medicine for thousands of years in Asian countries. Several in vitro and in vivo studies have shown that this plant not only reduces the incidence of colorectal cancer, but also improves patient's status by enhancing the effects of chemotherapy drugs. However, further studies are needed to prove this relationship. We briefly review ginseng and its components such as ginsenosides reported anticancer effects and their mechanisms of action. Understanding these relationships may produce insights into chemical and pharmacological approaches for enhancing the chemo preventive effects of ginsenosides and for developing novel anticancer agents.
结直肠癌是全球最常见的疾病之一。早期筛查和开始化疗对降低死亡率有效。这种类型的癌症可以通过富含水果和蔬菜的健康饮食在一定程度上得到控制。人参是一种在亚洲国家作为草药食用了数千年的植物。多项体外和体内研究表明，这种植物不仅能降低结直肠癌的发病率，还能通过增强化疗药物的效果来改善患者状况。然而，需要进一步研究来证实这种关系。我们简要回顾人参及其成分（如人参皂苷）的抗癌作用及其作用机制。了解这些关系可能会为增强人参皂苷的化学预防作用和开发新型抗癌药物的化学和药理学方法提供见解。
