Gursu Meltem, Celik Kenan, Ozturk Savas, Turkmen Aydin, Gorcin Serpil, Kocak Burak, Sari Soner, Koldas Macit, Feyizoglu Hikmet, Kazancioglu Rumeyza
From the Department of Nephrology, Haseki Training and Research Hospital, Istanbul, Turkey.
Exp Clin Transplant. 2014 Aug;12(4):295-9. doi: 10.6002/ect.2013.0122. Epub 2014 Feb 25.
There are numerous changes in inflammatory status that occur after a kidney transplant. Pentraxin 3 is a marker of inflammation, but little information is available about pentraxin 3 levels after a kidney transplant. We evaluated the relation between pentraxin 3 and other inflammatory markers including high sensitivity C-reactive protein, interleukin 6, and tumor necrosis factor alpha in kidney transplant recipients.
Adult patients (40 patients; aged, 18-80 y; mean age, 38 ± 10 y) who had a kidney transplant from living-related donors were studied. Patients who had comorbidities associated with chronic inflammation were excluded. Blood samples were obtained before starting immunosuppressive treatment and 2 months after kidney transplant for measurement of pentraxin 3, high sensitivity C-reactive protein, interleukin 6, and tumor necrosis factor α levels.
After transplant, mean levels of high sensitivity C-reactive protein and interleukin 6 decreased but levels of pentraxin 3 and tumor necrosis factor alpha did not change. There were significant correlations between interleukin 6 and high sensitivity C-reactive protein before transplant (r = 0.71; P ≤ .0001) and after transplant (r = 0.45; P ≤ .003). There was no correlation between tumor necrosis factor alpha and high sensitivity C-reactive protein before transplant, but there was a significant correlation between tumor necrosis factor alpha and high sensitivity C-reactive protein after transplant (r = 0.36; P ≤ .03). There was no correlation between interleukin 6 and pentraxin 3, tumor necrosis factor alpha and pentraxin 3, or high sensitivity C-reactive protein and pentraxin 3 before or after transplant.
After a kidney transplant, pentraxin 3 may not be useful in determining inflammatory status, and high sensitivity C-reactive protein may be better than pentraxin 3 as a marker of inflammation.
肾移植后炎症状态会发生诸多变化。五聚素3是一种炎症标志物，但关于肾移植后五聚素3水平的信息较少。我们评估了肾移植受者中五聚素3与其他炎症标志物（包括高敏C反应蛋白、白细胞介素6和肿瘤坏死因子α）之间的关系。
研究对象为接受活体亲属供肾肾移植的成年患者（40例；年龄18 - 80岁；平均年龄38±10岁）。排除患有与慢性炎症相关合并症的患者。在开始免疫抑制治疗前及肾移植后2个月采集血样，以测定五聚素3、高敏C反应蛋白、白细胞介素6和肿瘤坏死因子α水平。
移植后，高敏C反应蛋白和白细胞介素6的平均水平下降，但五聚素3和肿瘤坏死因子α的水平未发生变化。移植前白细胞介素6与高敏C反应蛋白之间存在显著相关性（r = 0.71；P≤.0001），移植后也存在显著相关性（r = 0.45；P≤.003）。移植前肿瘤坏死因子α与高敏C反应蛋白之间无相关性，但移植后肿瘤坏死因子α与高敏C反应蛋白之间存在显著相关性（r = 0.36；P≤.03）。移植前后白细胞介素6与五聚素3、肿瘤坏死因子α与五聚素3、高敏C反应蛋白与五聚素3之间均无相关性。
肾移植后，五聚素3可能无助于确定炎症状态，高敏C反应蛋白作为炎症标志物可能比五聚素3更优。
