Uzun Sami, Kaya Burcu, Celik Kenan, Behlul Ahmet, Ozkan Oktay, Kuvvet Melike, Doventas Yasemin Erdogan, Gursu Meltem, Karadag Serhat, Sumnu Abdullah, Cebeci Egemen, Kocak Burak, Turkmen Aydın, Ozturk Savas
Department of Nephrology, Haseki Training and Research Hospital, Istanbul - Turkey.
Department of Internal Diseases, Haseki Training and Research Hospital, Istanbul - Turkey.
Int J Artif Organs. 2016 Aug 19;39(6):277-81. doi: 10.5301/ijao.5000510. Epub 2016 Jul 23.
Midkine (MK), which is expressed in the proximal tubular epithelial cells of the kidney, is thought to have a role in the pathophysiology of inflammation-related renal diseases. Both immunological and nonimmunological mechanisms may affect renal functions negatively during the early and late post-transplantation periods. We aimed in our study to evaluate the relationship of MK with clinical findings and inflammatory markers, including high sensitivity C-reactive protein (hs-CRP), interleukin (IL-6) and tumor necrosis factor (TNF-α) in the pretransplant and post-transplant period.
Forty-one consecutive patients transplanted from living related donors were included in this prospective observational study. All patients received the same immunosuppressive treatment protocol. MK, hsCRP, IL-6 and TNF-α levels were measured before and 2 months after renal transplantation.
Pretransplant MK levels correlated positively with hsCRP (r = 0.41, p = 0.004) and IL-6 (r = 0.58, p<0.001). The mean post-transplant MK level was found to be higher than the pretransplant level (143 ± 350 pg/mL, 2792 ± 4235 pg/mL respectively, p = <0.001), while the mean hsCRP, IL-6 and TNF-α levels did not change significantly. Post-transplant IL-6 correlated significantly with MK (r = 0.388, p = 0.012), hsCRP (r = 0.41, p = 0.007) and TNF-α (r = 0.348, p = 0.026). There was no significant correlation between clinical findings and inflammatory markers.
MK may be a good inflammatory marker in renal transplant recipients as in other inflammatory diseases. Moreover, it seems that it is not affected by factors other than inflammation during the post-transplantation period.
中期因子（MK）在肾脏近端肾小管上皮细胞中表达，被认为在炎症相关肾脏疾病的病理生理学中发挥作用。免疫和非免疫机制在移植后的早期和晚期都可能对肾功能产生负面影响。我们的研究旨在评估移植前后MK与临床发现及炎症标志物之间的关系，这些炎症标志物包括高敏C反应蛋白（hs-CRP）、白细胞介素（IL-6）和肿瘤坏死因子（TNF-α）。
本前瞻性观察研究纳入了41例来自活体亲属供体的连续移植患者。所有患者均接受相同的免疫抑制治疗方案。在肾移植前及移植后2个月测量MK、hsCRP、IL-6和TNF-α水平。
移植前MK水平与hsCRP（r = 0.41，p = 0.004）和IL-6（r = 0.58，p<0.001）呈正相关。发现移植后MK的平均水平高于移植前水平（分别为143±350 pg/mL和2792±4235 pg/mL，p = <0.001），而hsCRP、IL-6和TNF-α的平均水平没有显著变化。移植后IL-6与MK（r = 0.388，p = 0.
