Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Nat Genet. 2014 Mar;46(3):214-5. doi: 10.1038/ng.2904.
Clear cell renal cell carcinoma (CCRCC) is characterized by mutation of the VHL gene and loss of a segment of chromosome 3. A new study using multi-region exome sequencing has identified substantial intratumoral heterogeneity within large primary CCRCCs, which has profound implications for understanding tumor evolution and for developing effective therapies.
透明细胞肾细胞癌（CCRCC）的特征是 VHL 基因突变和 3 号染色体部分缺失。一项新的使用多区域外显子组测序的研究表明，大型原发性 CCRCC 内存在大量肿瘤内异质性，这对理解肿瘤进化和开发有效疗法具有深远意义。
