一名患有遗传性STAT1缺陷的青少年的苏尔加分枝杆菌慢性多灶性骨髓炎。

Mycobacterium szulgai chronic multifocal osteomyelitis in an adolescent with inherited STAT1 deficiency.

作者信息

Shamriz Oded, Engelhard Dan, Rajs Andrea Psorn, Kaidar-Shwartz Hasia, Casanova Jean-Laurent, Averbuch Diana

机构信息

From the *Department of Pediatrics; †Pediatric Infectious Diseases Unit, Hadassah-Hebrew University Medical Center, Ein Kerem, Jerusalem, Israel; ‡School of Primary Health Care, Monash University, Melbourne, Victoria, Australia; §Department of Microbiology, Hadassah-Hebrew University Medical Center, Ein Kerem, Jerusalem; ¶National Mycobacterium Reference Laboratory, National Public Health Laboratory, Ministry of Health, Tel Aviv, Israel; and ‖St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY.

出版信息

Pediatr Infect Dis J. 2013 Dec;32(12):1345-7. doi: 10.1097/01.inf.0000437067.43859.4c.

DOI:10.1097/01.inf.0000437067.43859.4c

PMID:24569307

Abstract

We report a 17-year-old patient with inherited STAT1 deficiency, who was diagnosed with Mycobacterium szulgai chronic multifocal osteomyelitis and responded well to the therapy with ethambutol, rifampicin and azithromycin. Seven other reported cases of M. szulgai osteomyelitis are reviewed. This is the first description of M. szulgai osteomyelitis in an adolescent with a primary immunodeficiency.

摘要

我们报告了一名患有遗传性STAT1缺陷的17岁患者，该患者被诊断为苏尔加分枝杆菌慢性多灶性骨髓炎，对乙胺丁醇、利福平和阿奇霉素治疗反应良好。我们还回顾了其他7例已报道的苏尔加分枝杆菌骨髓炎病例。这是首次对一名患有原发性免疫缺陷的青少年的苏尔加分枝杆菌骨髓炎进行描述。