Weng Tzu-Ping, Syue Ling-Shan, Lee Nan-Yao
Department of Internal Medicine, National Cheng Kung University Hospital Tainan, Taiwan.
Center for Infection Control, National Cheng Kung University Hospital Tainan, Taiwan.
IDCases. 2020 May 28;21:e00848. doi: 10.1016/j.idcr.2020.e00848. eCollection 2020.
Incidence of nontuberculous mycobacterial infections has increased during the past decades. Disseminated infections are relatively rare and associated with immunocompromised status. We report a case of disseminated infection of cervical lymphadenitis and pulmonary involvement with positive anti-interferon-gamma autoantibodies. The patient was successfully treated with rifampin, ethambutol, and clarithromycin. The case reports and series through search engines of Pubmed and Google with the keyword of disseminated infection of were reviewed. Fifteen patients of disseminated infection were reviewed and included. Disseminatedinfection involves bone, skin and lymph node more common instead of pulmonary involvement, and most are associated with immunocompromised status with neoplastic hematologic disorders. In patients with disseminated infection, long term anti-mycobacterial agents are necessary. Most patients will respond to rifampin and ethambutol combination regimens.
在过去几十年中，非结核分枝杆菌感染的发病率有所上升。播散性感染相对罕见，且与免疫功能低下状态相关。我们报告一例伴有抗干扰素-γ自身抗体阳性的播散性颈淋巴结炎和肺部受累感染病例。该患者接受利福平、乙胺丁醇和克拉霉素治疗后痊愈。通过PubMed和谷歌搜索引擎，以播散性感染为关键词，对病例报告和系列研究进行了综述。共纳入并综述了15例播散性感染患者。播散性感染更常见于累及骨骼、皮肤和淋巴结，而非肺部受累，且大多数与免疫功能低下状态及血液系统肿瘤性疾病相关。对于播散性感染患者，长期使用抗分枝杆菌药物是必要的。大多数患者对利福平和乙胺丁醇联合治疗方案有反应。
