Cottone M, Turri M, Caltagirone M, Maringhini A, Sciarrino E, Virdone R, Fusco G, Orlando A, Marino L, Pagliaro L
Department of Medicine, Ospedale Cervello, Palermo, Italy.
Hepatogastroenterology. 1988 Jun;35(3):101-3.
A prospective surveillance of hepatocellular carcinoma (HCC) associated with cirrhosis, using alfafetoprotein (AFP) and real-time ultrasonography (US) was carried out in 157 patients with histologically proven cirrhosis. During a two-year follow-up, 15 asymptomatic HCCs were identified. HCCs detected by these methods were at a relatively early stage, as most tumors were small (13 out of 15 less than 5 cm). US was more sensitive than AFP in the diagnosis of HCC when values greater than 400 ng/ml were considered. Patients with initial AFP values greater than 20 ng/ml developed HCC within two years more frequently than patients with values less than 20 ng/ml. A combined approach using US and AFP is suggested in our geographical area.
对157例经组织学证实为肝硬化的患者进行了一项前瞻性监测，采用甲胎蛋白（AFP）和实时超声检查（US）来监测与肝硬化相关的肝细胞癌（HCC）。在为期两年的随访期间，共发现15例无症状性HCC。通过这些方法检测出的HCC处于相对早期阶段，因为大多数肿瘤较小（15例中有13例小于5厘米）。当AFP值大于400 ng/ml时，超声检查在HCC诊断中比AFP更敏感。初始AFP值大于20 ng/ml的患者在两年内发生HCC的频率高于AFP值小于20 ng/ml的患者。在我们所在地区，建议采用超声检查和AFP相结合的方法。
