C3H小鼠可移植性成红细胞白血病的建立与特性研究

Establishment and characterization of a transplantable erythroblastic leukemia in C3H mice.

作者信息

Itoh K, Ono K, Sawada H, Tezuka H, Sakoda H, Nakane H, Uchiyama T, Uchino H, Mori K J

机构信息

Department of Biology, Faculty of Science, Niigata University, Japan.

出版信息

Leuk Res. 1988;12(6):471-8. doi: 10.1016/0145-2126(88)90113-0.

DOI:10.1016/0145-2126(88)90113-0

PMID:2457136

Abstract

A disease with the characteristics of an erythroblastic leukemia was induced by X-ray irradiation of 300 Rads in C3H mice. The leukemia is transplantable in syngeneic mice by i.v. injection of the spleen cells. The mice show almost pure erythroid cells of various differentiation stages in peripheral blood. The number of total nucleated cells in the peripheral blood increased, but hematocrit and platelet number decreased. Reverse transcriptase activities were measured in spleen and liver of the mice and the data suggested that the leukemia was not induced by retrovirus infection. This leukemia is distinguishable, in this respect, from diseases reported by Friend or Rauscher. The leukemia will offer a good animal model for the studies on non-viral leukemogenesis and disorders of erythropoiesis.

摘要

用300拉德的X射线照射C3H小鼠诱发了一种具有成红细胞白血病特征的疾病。通过静脉注射脾细胞，这种白血病可在同基因小鼠中移植。小鼠外周血中显示出几乎是处于各种分化阶段的纯红细胞。外周血中总核细胞数量增加，但血细胞比容和血小板数量减少。在小鼠的脾脏和肝脏中测量了逆转录酶活性，数据表明这种白血病不是由逆转录病毒感染诱发的。在这方面，这种白血病与Friend或Rauscher报道的疾病不同。这种白血病将为非病毒白血病发生和红细胞生成障碍的研究提供一个良好的动物模型。