Nara N, Hirashima K, Momoi H
Acta Haematol. 1981;66(3):168-73. doi: 10.1159/000207115.
Erythroleukemia occurred in a BCF1 mouse after X-irradiation. This leukemia was maintained by leukemic cell transplantation successively without changes in the characters of leukemia. According to leukemic cell proliferation, peripheral blood leukemic cells increased in number, and anemia and granulocytopenia developed. Following leukemic cell infiltration, granuloid-committed stem cells (CFU-C) in bone marrow decreased but those in spleen increased. Neither leukemic cells nor leukemic cell-conditioned medium inhibited CFU-C culture in vitro. Effects of leukemic cells on hematopoiesis were discussed.
一只BCF1小鼠在接受X射线照射后发生了红白血病。这种白血病通过白血病细胞移植得以连续维持，白血病的特征没有改变。随着白血病细胞的增殖，外周血中的白血病细胞数量增加，出现了贫血和粒细胞减少。白血病细胞浸润后，骨髓中粒系定向干细胞（CFU-C）减少，但脾脏中的增加。白血病细胞及其条件培养液在体外均不抑制CFU-C培养。本文讨论了白血病细胞对造血的影响。
