Thumwood C M, Hunt N H, Clark I A, Cowden W B
Department of Experimental Pathology, John Curtin School of Medical Research, Australian National University, Canberra.
Parasitology. 1988 Jun;96 ( Pt 3):579-89. doi: 10.1017/s0031182000080203.
Cerebral malaria in A/J and CBA/H mice infected with Plasmodium berghei ANKA is accompanied by mononuclear cell infiltration, haemorrhage and cerebral endothelial cell damage. This damage is presumably one of the causes of the breakdown of the blood-brain barrier which was detected by measuring the movement of the dye Evans blue and radioisotope labelled albumin and erythrocytes. The density of brain tissue, measured by a Percoll gradient technique, was significantly reduced in mice exhibiting cerebral symptoms, suggesting the occurrence of cerebral oedema.
感染伯氏疟原虫ANKA的A/J和CBA/H小鼠发生脑型疟疾时，伴有单核细胞浸润、出血和脑内皮细胞损伤。这种损伤可能是血脑屏障破坏的原因之一，血脑屏障的破坏是通过测量染料伊文思蓝以及放射性同位素标记的白蛋白和红细胞的移动来检测的。采用Percoll梯度技术测量脑组织密度，发现出现脑部症状的小鼠脑组织密度显著降低，提示发生了脑水肿。
