反复接触林丹和镉对大鼠体内林丹代谢的影响。

Effect of repeated exposure to lindane and cadmium on lindane metabolism in rats.

作者信息

Khanna R N, Anand M, Gopal K, Varma N, Gupta G S, Ray P K

机构信息

Industrial Toxicology Research Centre, Lucknow, India.

出版信息

Toxicol Lett. 1988 Aug;42(2):177-82. doi: 10.1016/0378-4274(88)90075-6.

DOI:10.1016/0378-4274(88)90075-6

PMID:2457263

Abstract

The effects of daily administration of cadmium and lindane for 35 days on the metabolism of lindane in rats were investigated. The results indicate that cadmium induces a significant inhibition of lindane metabolism, since the group dosed with lindane plus cadmium had a significantly higher concentration of lindane in plasma and tissues than the group dosed with lindane alone. The inhibition in the metabolic rate of lindane is associated with the cadmium-induced alterations in the disposition of essential trace elements, Zn, Cu and Fe, in the liver.

摘要

研究了连续35天每日给予大鼠镉和林丹对林丹代谢的影响。结果表明，镉可显著抑制林丹代谢，因为给予林丹加镉的组血浆和组织中林丹的浓度显著高于仅给予林丹的组。林丹代谢率的抑制与镉诱导的肝脏中必需微量元素锌、铜和铁分布的改变有关。