Palmer A M, Stratmann G C, Procter A W, Bowen D M
Miriam Marks Department of Neurochemistry, Institute of Neurology, Unversity of London, UK.
Ann Neurol. 1988 Jun;23(6):616-20. doi: 10.1002/ana.410230616.
Serotonin, 5-hydroxyindoleacetic acid, and homovanillic acid concentrations have been determined in 10 areas of the cerebral cortex from 17 subjects with Alzheimer's disease and 18 control subjects. The dopamine metabolite was not reduced in any area, whereas both indoleamines were reduced in the superior frontal, inferior temporal, and fusiform gyri, and the temporal pole. These areas and areas of the parietal cortex, where there were no changes in concentration, have not previously been reported on. We argue that the large loss of indoleamines from the frontal lobe (to 50-63% of control values) is rather unexpected based on other biochemical measurements and may relate to behavioral changes.
已测定了17名阿尔茨海默病患者和18名对照者大脑皮质10个区域中血清素、5-羟吲哚乙酸和高香草酸的浓度。多巴胺代谢物在任何区域均未减少，而两种吲哚胺在额上回、颞下回、梭状回和颞极均减少。顶叶皮质中浓度未发生变化的这些区域以及其他区域，此前未见报道。我们认为，基于其他生化测量，额叶中吲哚胺大量减少（降至对照值的50%-63%）相当出乎意料，且可能与行为变化有关。
