Department of Psychiatry, Neurology, Pharmacology and Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Indian J Psychiatry. 2014 Jan;56(1):46-53. doi: 10.4103/0019-5545.124746.
Hyperhomocysteinemia has been associated with psychiatric diseases in non-Indian populations.
We aimed to determine if total plasma Homocysteine (Hcys) is associated with schizophrenia or depression in South Indian Tamil patients and if so, to correlate their severity and phenomenology to Hcys levels.
40 patients each with schizophrenia and depression and 40 healthy controls were recruited from the psychiatry department of a quaternary referral centre. Association between Hcys and psychiatric disorders was determined using a Case- control design. Hcys levels were correlated with age, gender and severity and duration of the disease by appropriate statistical methods using SPSS17.
Schizophrenia and depression were defined using ICD10 DCR version. Severity of depression was assessed by Hamilton Depression Rating Scale and that of schizophrenia using Positive and Negative Schizophrenia scales (PANSS). Hcys levels were determined using automated chemiluminiscence immunoassay (74-76).
Differences between the mean values of plasma homocysteine levels among schizophrenia, depression and control groups were compared using analysis of variants. The association between the severity and duration of schizophrenia and depression and the plasma homocysteine levels were determine using Pearson correlation.
In Tamilian population, schizophrenia and depression are associated with total plasma Hcys levels which correlated with the duration and severity of psychosis.
高同型半胱氨酸血症与非印度人群的精神疾病有关。
我们旨在确定总血浆同型半胱氨酸（Hcys）是否与南印度泰米尔患者的精神分裂症或抑郁症有关，如果是，将其严重程度和表型与 Hcys 水平相关联。
从一家四级转诊中心的精神病科招募了 40 名精神分裂症患者、40 名抑郁症患者和 40 名健康对照者。使用病例对照设计确定 Hcys 与精神疾病之间的关联。使用适当的统计方法（使用 SPSS17），通过适当的统计方法，将 Hcys 水平与年龄、性别以及疾病的严重程度和持续时间相关联。
使用 ICD10 DCR 版本定义精神分裂症和抑郁症。使用汉密尔顿抑郁评定量表评估抑郁症的严重程度，使用阳性和阴性精神分裂症量表（PANSS）评估精神分裂症的严重程度。使用自动化化学发光免疫测定法（74-76）测定 Hcys 水平。
使用方差分析比较精神分裂症、抑郁症和对照组之间血浆同型半胱氨酸水平的平均值差异。使用 Pearson 相关分析确定精神分裂症和抑郁症的严重程度和持续时间与血浆同型半胱氨酸水平之间的关联。
在泰米尔人群中，精神分裂症和抑郁症与总血浆 Hcys 水平有关，与精神病的持续时间和严重程度有关。
