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从海洋来源真菌青霉属（Penicillium paxilli Ma(G)K.）中分离得到的 Pyrenocine A 具有很强的抗炎活性。

Potent anti-inflammatory activity of pyrenocine A isolated from the marine-derived fungus Penicillium paxilli Ma(G)K.

机构信息

Departamento de Ciências Biológicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista "Júlio de Mesquita Filho", 14801-902 Araraquara, SP, Brazil.

Departamento de Ciências Biológicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista "Júlio de Mesquita Filho", 14801-902 Araraquara, SP, Brazil ; Faculdade de Medicina Ribeirão Preto, Universidade de São Paulo, 14049-900 Ribeirão Preto, SP, Brazil.

出版信息

Mediators Inflamm. 2014;2014:767061. doi: 10.1155/2014/767061. Epub 2014 Jan 19.

DOI:10.1155/2014/767061
PMID:24574582
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3916108/
Abstract

Very little is known about the immunomodulatory potential of secondary metabolites isolated from marine microorganisms. In the present study, we characterized pyrenocine A, which is produced by the marine-derived fungus Penicillium paxilli Ma(G)K and possesses anti-inflammatory activity. Pyrenocine A was able to suppress, both pretreatment and posttreatment, the LPS-induced activation of macrophages via the inhibition of nitrite production and the synthesis of inflammatory cytokines and PGE2. Pyrenocine A also exhibited anti-inflammatory effects on the expression of receptors directly related to cell migration (Mac-1) as well as costimulatory molecules involved in lymphocyte activation (B7.1). Nitrite production was inhibited by pyrenocine A in macrophages stimulated with CpG but not Poly I:C, suggesting that pyrenocine A acts through the MyD88-dependent intracellular signaling pathway. Moreover, pyrenocine A is also able to inhibit the expression of genes related to NF κ B-mediated signal transduction on macrophages stimulated by LPS. Our results indicate that pyrenocine A has promissory anti-inflammatory properties and additional experiments are necessary to confirm this finding in vivo model.

摘要

关于从海洋微生物中分离得到的次生代谢产物的免疫调节潜力，人们知之甚少。在本研究中，我们对来源于海洋真菌青霉（Penicillium paxilli Ma(G)K）的具有抗炎活性的化合物pyrenocine A 进行了研究。Pyrenocine A 能够通过抑制亚硝酸盐的产生以及炎症细胞因子和 PGE2 的合成，对 LPS 诱导的巨噬细胞激活进行预处理和后处理抑制。Pyrenocine A 还对与细胞迁移直接相关的受体（Mac-1）以及参与淋巴细胞激活的共刺激分子（B7.1）的表达表现出抗炎作用。Pyrenocine A 能够抑制 CpG 而非 Poly I:C 刺激的巨噬细胞中产生的亚硝酸盐，这表明 Pyrenocine A 通过 MyD88 依赖性细胞内信号通路发挥作用。此外，Pyrenocine A 还能够抑制 LPS 刺激的巨噬细胞中与 NF-κB 介导的信号转导相关的基因表达。我们的研究结果表明，Pyrenocine A 具有有前景的抗炎特性，需要进一步的体内实验来证实这一发现。

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