Gupta Anju, Saha Usha
Department of Anesthesiology and Intensive Care, Delhi State Cancer Hospital, Dilshad Garden, New Delhi, India.
LHMC and Associated Hospitals, New Delhi, India.
J Anaesthesiol Clin Pharmacol. 2014 Jan;30(1):10-8. doi: 10.4103/0970-9185.125687.
Even after a vast safety record, the role of spinal anesthesia (SA) as a primary anesthetic technique in children remains contentious and is mainly limited to specialized pediatric centers. It is usually practiced on moribund former preterm infants (<60 weeks post-conception) to reduce the incidence of post-operative apnea when compared to general anesthesia (GA). However, there is ample literature to suggest its safety and efficacy for suitable procedures in older children as well. SA in children has many advantages as in adults with an added advantage of minimal cardio-respiratory disturbance. Recently, several reports from animal studies have raised serious concerns regarding the harmful effects of GA on young developing brain. This may further increase the utility of SA in children as it provides all components of balanced anesthesia technique. Also, SA can be an economical option for countries with finite resources. Limited duration of surgical anesthesia in children is one of the major deterrents for its widespread use in them. To overcome this, several additives like epinephrine, clonidine, fentanyl, morphine, neostigmine etc. have been used and found to be effective even in neonates. But, the developing spinal cord may also be vulnerable to drug-related toxicity, though this has not been systematically evaluated in children. So, adjuvants and drugs with widest therapeutic index should be preferred in children. Despite its widespread use, incidence of side-effects is low and permanent neurological sequalae have not been reported with SA. Literature yields encouraging results regarding its safety and efficacy. Technical skills and constant vigilance of experienced anesthesia providers is indispensable to achieve good results with this technique.
即便有着大量的安全记录,但脊髓麻醉(SA)作为儿童主要麻醉技术的作用仍存在争议,且主要局限于专业的儿科中心。与全身麻醉(GA)相比,脊髓麻醉通常用于濒死的既往早产儿(孕龄小于60周)以降低术后呼吸暂停的发生率。然而,也有大量文献表明其在大龄儿童进行合适手术时同样具有安全性和有效性。儿童脊髓麻醉与成人一样有诸多优点,还具有对心肺干扰最小的额外优势。最近,动物研究的几份报告引发了对全身麻醉对发育中的幼龄大脑有害影响的严重担忧。这可能会进一步增加脊髓麻醉在儿童中的应用,因为它提供了平衡麻醉技术的所有要素。此外,对于资源有限的国家,脊髓麻醉可能是一种经济的选择。儿童手术麻醉持续时间有限是其在儿童中广泛应用的主要阻碍之一。为克服这一问题,人们使用了多种添加剂,如肾上腺素、可乐定、芬太尼、吗啡、新斯的明等,并且发现即使在新生儿中也有效。但是,发育中的脊髓可能也易受药物相关毒性的影响,尽管这在儿童中尚未得到系统评估。因此,儿童应首选治疗指数最宽的佐剂和药物。尽管脊髓麻醉应用广泛,但其副作用发生率较低,且未报告有永久性神经后遗症。关于其安全性和有效性,文献给出了令人鼓舞的结果。经验丰富的麻醉人员的技术和持续警惕对于通过该技术取得良好效果必不可少。