Perrochon Anaïck, Kemoun Gilles, Dugué Benoit, Berthoz Alain
ISIS Research Institute on Disability and Ageing, Paris ; LPPA, UMR CNRS 7152, Collège de France, Paris ; Laboratoire Mobilité, Vieillissement et Exercice (MOVE), EA 6314, Université de Poitiers, Poitiers, France.
ISIS Research Institute on Disability and Ageing, Paris ; Laboratoire Mobilité, Vieillissement et Exercice (MOVE), EA 6314, Université de Poitiers, Poitiers, France.
Dement Geriatr Cogn Dis Extra. 2014 Jan 30;4(1):1-13. doi: 10.1159/000356727. eCollection 2014 Jan.
Subjects with mild cognitive impairment (MCI) have disturbances in their spatial navigation abilities and exhibit early deficits in visuospatial short-term memory. The purpose of the present study was to determine whether a quantitative (span score) and qualitative (evaluating navigation strategies used) analysis of the Corsi test (usual condition and complex navigation task) would be useful to reveal cognitive decline.
We evaluated the performance of 15 young adults, 21 healthy elderly subjects and 15 subjects with MCI using the electronic version of the Corsi test (the Modified Corsi Block-Tapping Test, MCBT) and the complex navigation task (the Modified Walking Corsi Test, MWCT). The MWCT, which is an adaptation of the Corsi test, assesses spatial memory when the subject walks in a complex environment. We used Richard et al.'s model [Cogn Sci 1993;17:497-529] to investigate problem-solving strategies during the Corsi tests.
The span scores obtained on the MCBT and the MWCT were significantly lower in the healthy elderly subjects (MCBT = 5.0 ± 0.7; MWCT = 4.0 ± 0.7) and the subjects with MCI (MCBT = 4.7 ± 0.8; MWCT = 4.1 ± 0.9) than in the younger adults (MCBT = 6.2 ± 0.6; MWCT = 5.3 ± 1.0). The visuospatial working memory was more impaired in the complex navigation task (MWCT = 4.3 ± 0.9) than in the modified Corsi test (MCBT = 5.3 ± 0.8). Finally, the subjects with greater cognitive impairment were more likely to have inadequate or absence of problem-solving strategies.
Investigating the problem-solving strategies used during the MWCT appears to be a promising way to differentiate between the subjects with MCI and the healthy elderly subjects.
轻度认知障碍（MCI）患者存在空间导航能力障碍，并在视觉空间短期记忆方面表现出早期缺陷。本研究的目的是确定对Corsi测试（常规条件和复杂导航任务）进行定量（跨度分数）和定性（评估所使用的导航策略）分析是否有助于揭示认知衰退。
我们使用Corsi测试的电子版（改良Corsi方块敲击测试，MCBT）和复杂导航任务（改良步行Corsi测试，MWCT）评估了15名年轻成年人、21名健康老年人和15名MCI患者的表现。MWCT是Corsi测试的一种改编形式，用于评估受试者在复杂环境中行走时的空间记忆。我们使用理查德等人的模型[《认知科学》1993年；17:497 - 529]来研究Corsi测试期间的问题解决策略。
健康老年人（MCBT = 5.0 ± 0.7；MWCT = 4.0 ± 0.7）和MCI患者（MCBT = 4.7 ± 0.8；MWCT = 4.1 ± 0.9）在MCBT和MWCT上获得的跨度分数显著低于年轻成年人（MCBT = 6.2 ± 0.6；MWCT = 5.3 ± 1.0）。与改良Corsi测试（MCBT = 5.3 ± 0.8）相比，复杂导航任务（MWCT = 4.3 ± 0.9）中的视觉空间工作记忆受损更严重。最后，认知障碍更严重的受试者更有可能没有或缺乏问题解决策略。
研究MWCT期间使用的问题解决策略似乎是区分MCI患者和健康老年人的一种有前景的方法。
