Houston Mark
Mark Houston, Hypertension Institute, Saint Thomas Medical Plaza, Nashville, TN 37205, United States.
World J Cardiol. 2014 Feb 26;6(2):38-66. doi: 10.4330/wjc.v6.i2.38.
Vascular biology, endothelial and vascular smooth muscle and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension, cardiovascular disease and target organ damage. Nutrient-gene interactions and epigenetics are predominant factors in promoting beneficial or detrimental effects in cardiovascular health and hypertension. Macronutrients and micronutrients can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.
血管生物学、内皮细胞与血管平滑肌以及心脏功能障碍在高血压、心血管疾病和靶器官损害的发生及持续发展中起主要作用。营养物质与基因的相互作用以及表观遗传学是影响心血管健康和高血压产生有益或有害效应的主要因素。大量营养素和微量营养素可通过多种与血管生物学相关的机制预防、控制和治疗高血压。氧化应激、炎症和自身免疫功能障碍引发并加剧高血压和心血管疾病。基于科学对照研究，选用单一或复合的营养补充剂、维生素、抗氧化剂和矿物质在治疗高血压方面具有一定作用，这些研究可补充优化营养，并结合其他生活方式的改变。
