伊朗马什哈德100例重型β地中海贫血患者的肝脏肿大及肝酶评估
Assessment Hepatomegaly and liver Enzymes in 100 Patients with beta Thalassemia Major in Mashhad, Iran.
作者信息
Hashemizadeh H, Noori R, Kolagari Sh
机构信息
Department of nursing, Quchan Branch, Islamic Azad University, Quchan, Iran.
Department of midwifery, Quchan Branch, Islamic Azad University, Quchan, Iran.
出版信息
Iran J Ped Hematol Oncol. 2012;2(4):171-7. Epub 2012 Sep 22.
BACKGROUND
Frequent blood transfusion in patients with beta thalassemia major can lead to iron overload especially in liver. Chronic iron overload could cause cirrhosis of the liver. Transfusion- transmitted hepatitis B and C also could develop cirrhosis in individuals.
MATERIALS AND METHODS
The present cross- sectional descriptive study is to assess hepatomegaly and liver enzymes in 100 patients with beta thalassemia major, ages between 2-18 years old. The study was carried out retrospectively. One hundred medical records have chosen from 400 samples of thalassemia major patients, who are under a regular care of the department of sarvar clinic.
RESULTS
Out of these patients, 55% were male and 45% female. The mean age of thalassemia patients was 10.8± 4.4 years. The mean and S. D of hemoglobin, ferritin, deferoxamine dosage was 8.5 ± 1.5g/dl , 2183 ± 1528 ng , 30 ± 11.16 mg/kg, respectively. Forty six percent of them had hepatomegaly. The mean and S. D of AST and ALT were 95± 70 IU/L and 70 ±35U/L respectively. Splenectomy was performed on 44% of patient.
CONCLUSION
Hepatomegaly is one of the most common findings in the thalassemic patient that induced with hemosiderosis and hepatitis.
背景
重型β地中海贫血患者频繁输血可导致铁过载，尤其是在肝脏。慢性铁过载可导致肝硬化。输血传播的乙型和丙型肝炎也可使个体发生肝硬化。
材料与方法
本横断面描述性研究旨在评估100例年龄在2至18岁之间的重型β地中海贫血患者的肝肿大和肝酶情况。该研究为回顾性研究。从sarvar诊所定期护理的400例重型地中海贫血患者样本中选取了100份病历。
结果
这些患者中，55%为男性，45%为女性。地中海贫血患者的平均年龄为10.8±4.4岁。血红蛋白、铁蛋白、去铁胺剂量的平均值和标准差分别为8.5±1.5g/dl、2183±1528ng、30±11.16mg/kg。其中46%有肝肿大。谷草转氨酶（AST）和谷丙转氨酶（ALT）的平均值和标准差分别为95±70IU/L和70±35U/L。44%的患者进行了脾切除术。
结论
肝肿大是地中海贫血患者最常见的表现之一，由含铁血黄素沉着症和肝炎引起。
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