生物相容性纳米金刚石-丝混合材料的合成与表征
Synthesis and characterization of biocompatible nanodiamond-silk hybrid material.
作者信息
Khalid Asma, Lodin Rebecca, Domachuk Peter, Tao Hu, Moreau Jodie E, Kaplan David L, Omenetto Fiorenzo G, Gibson Brant C, Tomljenovic-Hanic Snjezana
机构信息
School of Physics, University of Melbourne, Parkville, VIC 3010, Australia.
School of Physics, University of Sydney, Camperdown, NSW 2006, Australia.
出版信息
Biomed Opt Express. 2014 Jan 27;5(2):596-608. doi: 10.1364/BOE.5.000596. eCollection 2014 Feb 1.
Abstract
A new hybrid material consisting of nanodiamonds (NDs) and silk has been synthesized and investigated. NDs can contain bright fluorescence centers, important for bioprobes to image biological structures at the nanoscale and silk provides a transparent, robust matrix for these nanoparticles in-vivo or in-vitro. The ND-silk hybrid films were determined to be highly transparent in the visible to near infrared wavelength range. The NDs embedded in silk exhibited significant enhancement of emission relative to air, correlating with theoretical predictions. Furthermore, animal toxicity tests confirmed ND-silk films to be non-toxic in an in-vivo mice model.
摘要
一种由纳米金刚石（NDs）和丝绸组成的新型混合材料已被合成并研究。纳米金刚石可包含明亮的荧光中心，这对于生物探针在纳米尺度上成像生物结构很重要，而丝绸为这些纳米颗粒在体内或体外提供了一个透明、坚固的基质。经测定，纳米金刚石 - 丝绸混合薄膜在可见光到近红外波长范围内具有高透明度。嵌入丝绸中的纳米金刚石相对于在空气中时发射显著增强，这与理论预测相符。此外，动物毒性测试证实纳米金刚石 - 丝绸薄膜在体内小鼠模型中无毒。
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