Lua P L, Salihah N Z, Mazlan N
Centre for Clinical and Quality of Life Studies, Faculty of Medicine and Health Sciences, Universiti Sultan Zainal Abidin, Kampus Kota, Jalan Sultan Mahmud, 20400 Kuala Terengganu, Terengganu, Malaysia.
Kulliyyah of Allied Health Sciences, International Islamic University Malaysia Kuantan Campus, 25710 Kuantan, Pahang, Malaysia.
Malays J Nutr. 2012 Aug;18(2):173-84.
Nutritional decline is typically accepted as a consequent of the course of treatment for cancer. This study aimed to (1) assess body weight status and dietary intake of breast cancer patients on chemotherapy and (2) to correlate Body Mass Index (BMI), energy and protein intake with health-related quality of life (HRQoL) profile.
A cross-sectional study was conducted in two government hospitals in the East coast of Peninsular Malaysia using convenience sampling. Women aged > or =18 years, who were diagnosed with breast cancer and receiving chemotherapy were invited to participate. The following aspects were evaluated: body weight status, usual dietary intake (diet history) and HRQoL (EORTC QLQ-C30). Descriptive statistics and non-parametric tests were employed (SPSS 16).
Of the respondents, 41 were 49 +/- 9.6 years of age; 92.7% were Malay; 97.6% (response rate = 91%) were on moderately emetogenic chemotherapy. Over half of the patients were overweight or obese (mean BMI = 25.3 +/- 1.1 kg/m2). The majority self-reported weight reduction (46.3%) but positive energy balance was detected with the current energy and protein intakes recorded at 1792.6 +/- 304.9 kcal/day (range= 1200-2500) and 74.5 g/day (IqR= 37.7) respectively. Dietary intakes were, however, not correlated with HRQoL, but greater BMI was associated with better emotional and cognitive functioning and less fatigue.
Although most patients declared losing weight, obesity and excess dietary intake were noted. Additionally, body weight status has been shown to be important in HRQoL profile, underlining the necessity for effective nutritional assessments and support to the cancer population.
营养状况下降通常被认为是癌症治疗过程的一个后果。本研究旨在：（1）评估接受化疗的乳腺癌患者的体重状况和饮食摄入量；（2）将体重指数（BMI）、能量和蛋白质摄入量与健康相关生活质量（HRQoL）概况进行关联。
在马来西亚半岛东海岸的两家政府医院采用便利抽样法进行了一项横断面研究。邀请年龄≥18岁、被诊断患有乳腺癌且正在接受化疗的女性参与。评估了以下方面：体重状况、日常饮食摄入量（饮食史）和HRQoL（欧洲癌症研究与治疗组织QLQ-C30量表）。采用描述性统计和非参数检验（SPSS 16软件）。
在受访者中，41人年龄为49±9.6岁；92.7%为马来人；97.6%（应答率=91%）接受中度致吐性化疗。超过一半的患者超重或肥胖（平均BMI=25.3±1.1kg/m²）。大多数患者自述体重减轻（46.3%），但根据目前记录的能量和蛋白质摄入量分别为1792.6±304.9千卡/天（范围=1200 - 2500）和74.5克/天（四分位距=37.7），检测到正能量平衡。然而，饮食摄入量与HRQoL无关，但较高的BMI与更好的情绪和认知功能以及较少的疲劳相关。
尽管大多数患者宣称体重减轻，但仍存在肥胖和饮食摄入过量的情况。此外，体重状况已被证明在HRQoL概况中很重要，这凸显了对癌症患者进行有效营养评估和支持的必要性。
