在颅骨缺损模型中比较OsteoSelect脱矿骨基质油灰与NovaBone钙磷硅酸盐合成油灰的成骨潜力。

Comparison of the osteogenic potential of OsteoSelect demineralized bone matrix putty to NovaBone calcium-phosphosilicate synthetic putty in a cranial defect model.

作者信息

Schallenberger Mark A, Rossmeier Kerri, Lovick Helena M, Meyer Todd R, Aberman Harold M, Juda Gregory A

机构信息

From the *Bacterin International Inc, Belgrade, Montana; and†Applied Biological Concepts, Inc, Los Alamitos, California.

出版信息

J Craniofac Surg. 2014 Mar;25(2):657-61. doi: 10.1097/SCS.0000000000000610.

The purpose of this study was to compare the osteogenic potential of a synthetic and a demineralized bone matrix (DBM) putty using a cranial defect model in New Zealand white rabbits. Paired, bilateral critical-size defects (10 mm) were prepared in the frontal bones of 12 rabbits and filled with either OsteoSelect DBM Putty or NovaBone calcium-phosphosilicate putty. At days 43 and 91, 6 rabbits were killed and examined via semiquantitative histology and quantitative histomorphometry. Defects filled with the DBM putty were histologically associated with less inflammation and fibrous tissue in the defect and more new bone than the synthetic counterpart at both time points. Histomorphometric analysis revealed that the defects filled with DBM putty were associated with significantly more bone formation at day 43 (70.7% vs 40.7%, P = 0.043) and at day 91 (70.4% vs 39.9%, P = 0.0044). The amount of residual implant was similar for both test groups at each time point.

本研究的目的是使用新西兰白兔颅骨缺损模型，比较一种合成骨替代物和一种脱矿骨基质（DBM）油灰的成骨潜力。在12只兔子的额骨上制备配对的双侧临界尺寸缺损（10毫米），并用OsteoSelect DBM油灰或NovaBone钙磷硅酸盐油灰填充。在第43天和第91天，处死6只兔子，并通过半定量组织学和定量组织形态计量学进行检查。在两个时间点，与填充合成骨替代物的缺损相比，填充DBM油灰的缺损在组织学上与缺损处较少的炎症和纤维组织以及较多的新骨相关。组织形态计量学分析显示，填充DBM油灰的缺损在第43天（70.7%对40.7%，P = 0.043）和第91天（70.4%对39.9%，P = 0.0044）与显著更多的骨形成相关。在每个时间点，两个测试组的残余植入物量相似。