来自硬叶女娄菜的细胞毒性蒽醌二聚体。
Cytotoxic anthraquinone dimers from Melandrium firmum.
作者信息
Zhang Chang-Hao, Yao Da-Lei, Li Cheng-Shen, Luo Jie, Jin Mei, Zheng Ming-Shan, Lin Zhen-Hua, Jin Tie-Feng, Li Gao
机构信息
Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules, Yanbian University College of Pharmacy, Yanji, 133002, China.
出版信息
Arch Pharm Res. 2015 Jun;38(6):1033-7. doi: 10.1007/s12272-014-0360-2. Epub 2014 Feb 28.
Two new anthraquinone dimers, melrubiellin A (1) and melrubiellin B (2), were isolated from the aerial part of Melandrium firmum Rohrbach, along with seven known compounds (3-9). The structures of these compounds were elucidated by spectral analyses, including 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) experiments. Compound 1 and 2 exhibited significant cytotoxicity towards HeLa, NCI-H460, Hep G2, Hep 3B and MKN-28 cell lines with IC50 values ranging from 5.26 to 81.16 μM.
从硬毛女娄菜（Melandrium firmum Rohrbach）的地上部分分离出两种新的蒽醌二聚体，即黑麦草素A（1）和黑麦草素B（2），以及七种已知化合物（3 - 9）。通过光谱分析，包括一维和二维核磁共振（COSY、HMQC、HMBC和NOESY）实验，阐明了这些化合物的结构。化合物1和2对HeLa、NCI - H460、Hep G2、Hep 3B和MKN - 28细胞系表现出显著的细胞毒性，IC50值范围为5.26至81.16 μM。
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