来自双翅果蜜茱萸的具有细胞毒性和抗炎作用的四环三萜类化合物。
Cytotoxic and anti-inflammatory tirucallane triterpenoids from Dysoxylum binectariferum.
作者信息
Hu Jiang, Song Yan, Li Hui, Yang Benshou, Mao Xia, Zhao YongMao, Shi Xiaodong
机构信息
College of Biological Resources and Environment Science, Qujing Normal University, Qujing 655011, Yunnan, China.
Department of Pharmacy, 455 Hospital of People's Liberation Army, Shanghai 200052, China.
出版信息
Fitoterapia. 2014 Dec;99:86-91. doi: 10.1016/j.fitote.2014.09.010. Epub 2014 Sep 22.
Four new tirucallane triterpenoids 1-4 along with two known compounds 5 and 6 were isolated from the stem bark of Dysoxylum binectariferum. Their structures were elucidated on the basis of extensive 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) analyses. The isolated compounds were evaluated in vitro for anti-inflammatory and cytotoxic potential against eight tumor cell lines. Compounds 1-6 exhibited significant selective inhibition of Cox-1 and selectively significant cytotoxic against five tumor cell lines (A-549, HCT15, HepG2, SGC-7901 and SK-MEL-2), especially against HepG2 cell lines with IC₅₀ value of 7.5-9.5 μM.
从双腺荔枝的茎皮中分离出4个新的四环三萜类化合物1-4以及2个已知化合物5和6。通过广泛的一维和二维核磁共振（COSY、HMQC、HMBC和NOESY）分析确定了它们的结构。对分离得到的化合物进行体外抗炎活性和对8种肿瘤细胞系的细胞毒性评估。化合物1-6对Cox-1表现出显著的选择性抑制作用，对5种肿瘤细胞系（A-549、HCT15、HepG2、SGC-7901和SK-MEL-2）具有选择性显著细胞毒性，尤其是对HepG2细胞系，IC₅₀值为7.5-9.5 μM。
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