心血管疾病与糖尿病之间的关系：聚焦发病机制。
The relationships between cardiovascular disease and diabetes: focus on pathogenesis.
作者信息
Kovacic Jason C, Castellano Jose M, Farkouh Michael E, Fuster Valentin
机构信息
Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1030, New York, NY 10029, USA; Marie-Josée and Henry R. Kravis Cardiovascular Health Center, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1030, New York, NY 10029, USA.
Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1030, New York, NY 10029, USA; Marie-Josée and Henry R. Kravis Cardiovascular Health Center, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1030, New York, NY 10029, USA; Peter Munk Cardiac Centre and Heart and Stroke Richard Lewar Centre of Excellence, Cardiovascular Research, University of Toronto, MaRS Building 101 College Street, 3rd Floor, Toronto, ON M5G 1L7, Canada.
出版信息
Endocrinol Metab Clin North Am. 2014 Mar;43(1):41-57. doi: 10.1016/j.ecl.2013.09.007.
There is a looming global epidemic of obesity and diabetes. Of all the end-organ effects caused by diabetes, the cardiovascular system is particularly susceptible to the biologic perturbations caused by this disease, and many patients may die from diabetes-related cardiovascular complications. Substantial progress has been made in understanding the pathobiology of the diabetic vasculature and heart. Clinical studies have illuminated the optimal way to treat patients with cardiovascular manifestations of this disease. This article reviews these aspects of diabetes and the cardiovascular system, broadly classified into diabetic vascular disease, diabetic cardiomyopathy, and the clinical management of the diabetic cardiovascular disease patient.
肥胖和糖尿病正隐隐成为全球性流行病。在糖尿病引发的所有终末器官效应中，心血管系统尤其易受该疾病所导致的生物紊乱影响，许多患者可能死于糖尿病相关的心血管并发症。在理解糖尿病血管系统和心脏的病理生物学方面已取得了重大进展。临床研究阐明了治疗该疾病心血管表现患者的最佳方法。本文综述糖尿病与心血管系统的这些方面，大致分为糖尿病血管疾病、糖尿病心肌病以及糖尿病心血管疾病患者的临床管理。
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