Big Data Department, Health Insurance Review and Assessment, Won-ju, Gangwon, Republic of Korea.
Community Care Research Center, Health Insurance Research Institute, National Health Insurance Service, Won-ju, Gangwon, Republic of Korea.
Front Endocrinol (Lausanne). 2023 Jul 27;14:1230176. doi: 10.3389/fendo.2023.1230176. eCollection 2023.
Although the risk of coronavirus disease 2019 (COVID-19) infection is higher in patients who are diagnosed with diabetes than in those who are not, research on the risk of cardiovascular disease (CVD) in COVID-19 infected patients diagnosed with diabetes compared to those who are not infected by COVID-19 is lacking. This study aimed to examine the association between COVID-19, incidence of CVD, and all-cause mortality in patients with diabetes.
This study used data from the Health Insurance Review and Assessment, and included 16,779 patients with COVID-19 and 16,779 matched controls between January 2017 and June 2021. The outcomes included cardiovascular disease (CVD), coronary heart disease, stroke, and all-cause mortality. Cox proportional hazards regression models were used to evaluate these associations.
Patients with diabetes hospitalized because of COVID-19 had a significantly increased risk of CVD (adjusted hazard ratio [AHR], 2.12; 95% confidence interval [CI]: 1.97, 2.27) than those without COVID-19. The risks of coronary heart disease (AHR, 2.00; 95% CI: 1.85, 2.17) and stroke (AHR, 2.21; 95% CI: 1.90, 2.57) were higher in the intervention group than in the control group. In the case of all-cause mortality for middle-aged adults, we observed a higher risk in diabetes patients hospitalized due to COVID-19 than in patients without COVID-19 (AHR, 1.37; 95% CI: 1.18, 1.59).
This study showed that patients with diabetes hospitalized due to COVID-19 had an increased risk of CVD, coronary heart disease, stroke incidence, and mortality than those who were not COVID-19 infected, suggesting more careful prevention and management among patients with COVID-19.
虽然确诊糖尿病患者感染 2019 年冠状病毒病（COVID-19）的风险高于未确诊糖尿病患者，但 COVID-19 感染的糖尿病患者与未感染 COVID-19 的患者的心血管疾病（CVD）风险的研究尚缺乏。本研究旨在检查 COVID-19、CVD 发病和糖尿病患者全因死亡率之间的关联。
本研究使用了健康保险审查和评估的数据，包括 2017 年 1 月至 2021 年 6 月期间的 16779 例 COVID-19 患者和 16779 例匹配对照。结果包括心血管疾病（CVD）、冠心病、中风和全因死亡率。采用 Cox 比例风险回归模型评估这些关联。
因 COVID-19 住院的糖尿病患者发生 CVD 的风险显著增加（调整后的危险比 [AHR]，2.12；95%置信区间 [CI]：1.97，2.27），高于未感染 COVID-19 的患者。冠心病的风险（AHR，2.00；95% CI：1.85，2.17）和中风（AHR，2.21；95% CI：1.90，2.57）的风险在干预组中高于对照组。在中年成年人的全因死亡率方面，我们观察到 COVID-19 住院的糖尿病患者的风险高于未感染 COVID-19 的患者（AHR，1.37；95% CI：1.18，1.59）。
本研究表明，因 COVID-19 住院的糖尿病患者发生 CVD、冠心病、中风发病和死亡率的风险高于未感染 COVID-19 的患者，这表明 COVID-19 患者需要更仔细的预防和管理。
