Watson Peter N C, Evans Ramon J, Watt Verna R
Smythe Pain Clinic, Toronto General Hospital, University of Toronto, Toronto, Ont. M5G 2C4 Canada.
Pain. 1988 Jun;33(3):333-340. doi: 10.1016/0304-3959(88)90292-8.
Topical 0.025% capsaicin was used to treat 33 patients with post-herpetic neuralgia (PHN). Thirty-nine percent of those entering the trial achieved at least a good result and 55% were improved or better. Fifty-six percent of the 23 patients completing the study had good or excellent pain relief after 4 weeks. Seventy-eight percent of the 23 noted at least some improvement in pain. Post-capsaicin burning was a common, untoward effect in most patients and in about one-third was so unbearable that the trial was terminated prematurely. This treatment appears to be a useful modality in PHN, particularly in the elderly in whom oral medications are often poorly tolerated; however, it does require supervision. A double-blind, controlled trial is now necessary.
外用0.025%辣椒素用于治疗33例带状疱疹后神经痛（PHN）患者。参与试验的患者中有39%至少取得了良好的效果，55%的患者病情有所改善或更佳。完成研究的23例患者中，56%在4周后疼痛得到良好或极佳缓解。23例中有78%表示疼痛至少有一定程度的改善。辣椒素应用后的灼烧感是大多数患者常见的不良反应，约三分之一患者的灼烧感难以忍受，以至于试验提前终止。这种治疗方法似乎是治疗PHN的一种有效方式，尤其适用于口服药物耐受性通常较差的老年人；然而，它确实需要监督。现在有必要进行一项双盲对照试验。
